Confocal Microscopy in Ocular Argyrosis

Sánchez-Pulgarín, M.; Matilla, María Teresa; Martinez-de-la-Casa, José M.; Jerez, M.; Benítez-del-Castillo, J.M.

doi:10.1097/ico.0b013e3181b532fa

Cited by 14 publications

(22 citation statements)

References 9 publications

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“…Confocal microscopy examination of the cornea in our case revealed changes starting from anterior to mid-stroma through endothelium without epithelial involvement. The deposits appeared in a scattered fashion of hyperreflective dots as reported earlier [3]. The endothelium could not be visualized, probably due to highly reflective deposits increasing through deeper layers of the stroma.…”

Section: Commentsupporting

confidence: 59%

“…Although we did not confirm the corneal deposits by biopsy, conjunctival confocal microscopy results supported conjunctival histopathology results which approved argyrosis. As discussed earlier by Sánchez-Pulgarín et al [3] epithelial metaplasia of conjunctiva might correspond either to the silver deposits or to structural changes induced by the disease. …”

Section: Commentmentioning

confidence: 84%

“…Gray discoloration of the conjunctiva and scattered gray opacities in the cornea are clinical ocular manifestations of argyrosis [1–3]. Our patient had generalized argyria—conjunctival, corneal pigmentation as well as skin, nail, and dental pigmentation resulting from occupational contact.…”

Section: Commentmentioning

confidence: 92%

“…The endothelium could not be visualized, probably due to highly reflective deposits increasing through deeper layers of the stroma. However, Sánchez-Pulgarín et al [3] previously reported that the endothelium was normal in ocular argyrosis. Squamous metaplastic changes on conjunctival epithelium and diffuse highly reflective extracellular punctiform deposits in conjunctival substantia propria were detected on confocal microscopy as was demonstrated with histopathologic examination.…”

Section: Commentmentioning

confidence: 99%

“…Hands, eyes, and mucous membranes are affected in most of the patients, and discoloration of the ocular surface is the main ocular evidence [1–3]. A direct relationship was shown between the amount of discoloration and the length of time worked [1].…”

Section: Introductionmentioning

confidence: 99%

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Confocal Microscopy in Biopsy Proven Argyrosis

Palamar

Yılmaz

Eğrilmez

et al. 2013

Case Reports in Ophthalmological Medicine

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Purpose. To evaluate the confocal microscopy findings of a 46-year-old male with bilateral biopsy proven argyrosis. Materials and Methods. Besides routine ophthalmologic examination, anterior segment photography and confocal microscopy with cornea Rostoch module attached to HRT II (Heidelberg Engineering GmbH, Heidelberg, Germany) were performed. Findings. Squamous metaplastic changes on conjunctival epithelium and intense highly reflective extracellular punctiform deposits in conjunctival substantia propria were detected. Corneal epithelium was normal. Highly reflective punctiform deposits starting from anterior to mid-stroma and increasing through Descemet's membrane were evident. Corneal endothelium could not be evaluated due to intense stromal deposits. Conclusion. Confocal microscopy not only supports diagnosis in ocular argyrosis, but also demonstrates the intensity of the deposition in these patients.

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Section: Commentsupporting

confidence: 59%

Section: Commentmentioning

confidence: 84%

Section: Commentmentioning

confidence: 92%

Section: Commentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Confocal Microscopy in Biopsy Proven Argyrosis

Palamar

Yılmaz

Eğrilmez

et al. 2013

Case Reports in Ophthalmological Medicine

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Blaugraue Verfärbung von Haut und Bindehaut

Claessens¹,

Zeitz

Beckers³

2019

Ophthalmologe

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Diagnostic methods in ocular argyrosis: case report

2016

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PurposeThe aim of this report is to present a case of a patient, metal foundry worker, who had been exposed to industrial silver salts for over 20 years. It is well established that chronic exposure to silver compounds can cause accumulation of silver deposits in various tissues. This condition is referred to as argyrosis or argyria, whereas changes related to eye tissues are defined as ocular argyrosis.MethodsA complete eye examination, corneal confocal microscopy, kinetic and static visual field test, posterior segment optical coherent tomography, pattern visual evoked potentials (PVEP), flash visual evoked potentials, multifocal electroretinogram, pattern electroretinogram (PERG), full-field electroretinography (FERG) and electrooculogram were all performed.ResultsEye examination revealed decreased visual acuity, corneal deposits and drusenoid changes within the macula. Although electrophysiology tests did not show changes in the function of retinal pigment epithelium, they revealed abnormal function of photoreceptors in the central and peripheral retina. PERG abnormalities and delayed latency of P100 wave in PVEP confirmed impaired function of the inner layers of the retina in the macular region.ConclusionsCorneal confocal microscopy and electrophysiological tests may help confirm the diagnosis of ocular argyrosis.

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Confocal Microscopy in Ocular Argyrosis

Abstract: Confocal microscopy is a useful tool for the diagnosis of corneal argyrosis because it allows the in vivo visualization of silver deposits at different corneal levels.

Cited by 14 publications

References 9 publications

Confocal Microscopy in Biopsy Proven Argyrosis

Confocal Microscopy in Biopsy Proven Argyrosis

Blaugraue Verfärbung von Haut und Bindehaut

Diagnostic methods in ocular argyrosis: case report

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