Confocal microscopy in ocular surface disease

Потемкин, В. В.; Витальевич, Потёмкин Виталий; Varganova, Tatyana S.; Сергеевна, Варганова Татьяна; Агеева, Е. В.; Владимировна, Агеева Елена

doi:10.17816/ov1023-30

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…In our study, the density of corneal basal epithelial cells ranged from 7620 to 7828 cells/mm 2 , which is in agreement with previous literature reporting the density at the range of 3600 to 8996 cells/mm 2 . 46 Corneal nerve endings transduce stimuli into nerve signals that are directly responsible for physiological processes fundamental to ocular surface homeostasis. These include the activation of reflex blinking, tear reflex, neuropeptide secretion, and migratory and mitogenic effects of corneal epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

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Impact of Age on the Characteristics of Corneal Nerves and Corneal Epithelial Cells in Healthy Adults

Chin,

Liu,

Lee

et al. 2023

Cornea

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Purpose: The aim of this study was to investigate age-related changes in corneal nerves and corneal epithelial cell parameters and to establish age-adjusted reference values. Methods: A total of 7025 corneal nerve images and 4215 corneal epithelial images obtained using in vivo confocal microscopy from 281 eyes of 143 healthy participants were included. Seven corneal nerve parameters and 3 corneal epithelial cell parameters were quantified using 2 automatic analytic software and analyzed across 6 age groups ranging from 21 to 80 years. Results: There was a declining trend in all 7 nerve parameters with advancing age. In particular, corneal nerve fiber length and corneal nerve fiber density demonstrated a significant decrease in subjects aged 65 years or older compared with subjects younger than 65 years (10.8 ± 2.6 mm/mm2 vs. 9.9 ± 2.0 mm/mm2, P = 0.011 in corneal nerve fiber length; 15.8 ± 5.2 fibers/mm2 vs. 14.4 ± 4.3 fibers/mm2, P = 0.046 in corneal nerve fiber density), whereas corneal nerve fractal dimension demonstrated a borderline significant decrease (P = 0.057). Similarly, there was a general declining trend in all epithelial cell parameters with advancing age. Corneal epithelial cell circularity was significantly lower in subjects aged 65 years and older as compared to subjects younger than 65 years (0.722 ± 0.021 μm2 vs. 0.714 ± 0.021 μm2; P = 0.011). Conclusions: Advancing age results in reduced corneal nerve metrics and alteration of corneal cell morphology. Aging effects should be considered when evaluating patients with corneal neuropathy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Impact of Age on the Characteristics of Corneal Nerves and Corneal Epithelial Cells in Healthy Adults

Chin,

Liu,

Lee

et al. 2023

Cornea

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“…Возможно, одним из факторов, усугубляющим состояние поверхностных тканей, является изменение суббазального нервного сплетения роговицы. Ранее нами было продемонстрировано, что при ПЭС отмечается достоверно большее количество ветвей нервных волокон и увеличение количества гранулоподобных структур суббазальных нервных сплетений роговицы [2,4]. В данной статье продолжено изучение влияния факоэмульсификации (ФЭ) на состояние роговицы при наличии ПЭС [6].…”

Section: Introductionunclassified

Assessment of Corneal subbasal nerve plexus using confocal in vivo microscopy in patients with pseudoexfoliation syndrome after phacoemulsification

Potyomkin

Витальевич²,

Varganova

et al. 2018

Ophthalmology Reports

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Phacoemulsification (PE) is the leading method of cataract surgery. Purpose. To assess the impact of PE on corneal subbasal nerve plexus in patients with pseudoexfoliation syndrome (PEX) using confocal in vivo microscopy. Methods. 42 patients (42 eyes) were enrolled in the study. The main group consisted of 24 patients (24 eyes) with PEX syndrome, and 18 patients (18 eyes) without it composed the control group. Confocal in vivo microscopy was performed before and after PHACO. Results. In patients with PEX after PE, an increase in number of nerve branches and pellet-like structures in them were noticed (p < 0,05).

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“…Вместе с тем доказаны выраженные изменения тканей глазной поверхности при ПЭС [2,3,11,16]. Полученные данные показали зна-чительное снижение слезопродукции и времени разрыва слёзной плёнки, увеличение выражен-ности складок конъюнктивы, усиление прокра-шивания конъюнктивы витальными красителями и субъективных жалоб пациентов [2].…”

Section: Introductionunclassified

The influence of phacoemulsification on various corneal layers in patients with pseudoexfoliation syndrome assessed with confocal in vivo microscopy

Потемкин

Витальевич²,

Varganova

et al. 2017

Ophthalmology Reports

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Phacoemulsification (PHACO) is the basic procedure of cataract extraction. Purpose. To assess the impact of PHACO on corneal epithelium layers in patients with pseudoexfoliation syndrome (PEX) by confocal in vivo microscopy. Methods. 24 patients with PEX syndrome and 18 patients without it were enrolled in the prospective study. In vivo confocal microscopy was performed with assessment of cellular density in corneal epithelial layers, degree of its desquamation, degree of Bowman membrane stiffening and dendritic cells density. Results. The epithelial cells density didn’t change significantly in groups. Confocal microscopy showed high density of dendritic cells and marked desquamation of the epithelium in patients with PEX (p < 0,05) after PHACO. (For citation: Potemkin VV, Varganova TS, Terekhova IV, Ageeva EV. The influence of phacoemulsification on various corneal layers in patients with pseudoexfoliation syndrome assessed with confocal in vivo microscopy. Ophthalmology Journal. 2017;10(3):29-34. doi: 10.17816/OV10329-34).

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Confocal microscopy in ocular surface disease

Cited by 5 publications

References 23 publications

Impact of Age on the Characteristics of Corneal Nerves and Corneal Epithelial Cells in Healthy Adults

Impact of Age on the Characteristics of Corneal Nerves and Corneal Epithelial Cells in Healthy Adults

Assessment of Corneal subbasal nerve plexus using confocal in vivo microscopy in patients with pseudoexfoliation syndrome after phacoemulsification

The influence of phacoemulsification on various corneal layers in patients with pseudoexfoliation syndrome assessed with confocal in vivo microscopy

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