Confocal Neurolasermicroscopy - Modern Perspectives for Glioma Resection on a Cellular Level

Schlosser, Hans-Georg; Bojarski, Christian

doi:10.5772/24808

Advances in the Biology, Imaging and Therapies for Glioblastoma 2011

DOI: 10.5772/24808

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Confocal Neurolasermicroscopy - Modern Perspectives for Glioma Resection on a Cellular Level

Hans-Georg Schlosser¹,

Christian Bojarski²

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Cited by 2 publications

References 29 publications

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Soliton microcomb based spectral domain optical coherence tomography

et al. 2021

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Spectral domain optical coherence tomography (OCT) is a widely employed, minimally invasive bio-medical imaging technique, which requires a broadband light source, typically implemented by super-luminescent diodes. Recent advances in soliton based photonic integrated frequency combs (soliton microcombs) have enabled the development of low-noise, broadband chipscale frequency comb sources, whose potential for OCT imaging has not yet been unexplored. Here, we explore the use of dissipative Kerr soliton microcombs in spectral domain OCT and show that, by using photonic chipscale Si3N4 resonators in conjunction with 1300 nm pump lasers, spectral bandwidths exceeding those of commercial OCT sources are possible. We characterized the exceptional noise properties of our source (in comparison to conventional OCT sources) and demonstrate that the soliton states in microresonators exhibit a residual intensity noise floor at high offset frequencies that is ca. 3 dB lower than a traditional OCT source at identical power, and can exhibit significantly lower noise performance for powers at the milli-Watt level. Moreover, we demonstrate that classical amplitude noise of all soliton comb teeth are correlated, i.e., common mode, in contrast to superluminescent diodes or incoherent microcomb states, which opens a new avenue to improve imaging speed and performance beyond the thermal noise limit.

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Soliton microcomb based spectral domain optical coherence tomography

et al. 2021

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Confocal Laser Endomicroscopy for Real-time Histomorphological Diagnosis

et al. 2015

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Confocal Neurolasermicroscopy - Modern Perspectives for Glioma Resection on a Cellular Level

Cited by 2 publications

References 29 publications

Soliton microcomb based spectral domain optical coherence tomography

Soliton microcomb based spectral domain optical coherence tomography

Confocal Laser Endomicroscopy for Real-time Histomorphological Diagnosis

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