Conformal Arc Radiotherapy for Prostate Cancer: Increased Biochemical Failure in Patients With Distended Rectum on the Planning Computed Tomogram Despite Image Guidance by Implanted Markers

Engels, Benedikt; Soete, Guy; Verellen, Dirk; Storme, Guy

doi:10.1016/j.ijrobp.2008.08.007

Cited by 155 publications

(90 citation statements)

References 27 publications

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“…However, there is not much that suggests that it will provide a reduction in the side effects of the treatments with the currently used radiation doses 34 , 35 . The risk of recurrence has been shown to increase if the margin added to CTV is to small (36) . These conditions might change if higher radiation doses are introduced.…”

Section: Discussionmentioning

confidence: 99%

Comparison of manual and automatic MR‐CT registration for radiotherapy of prostate cancer

Korsager

Carl

Østergaard

2016

J Applied Clin Med Phys

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In image‐guided radiotherapy (IGRT) of prostate cancer, delineation of the clinical target volume (CTV) often relies on magnetic resonance (MR) because of its good soft‐tissue visualization. Registration of MR and computed tomography (CT) is required in order to add this accurate delineation to the dose planning CT. An automatic approach for local MR‐CT registration of the prostate has previously been developed using a voxel property‐based registration as an alternative to a manual landmark‐based registration. The aim of this study is to compare the two registration approaches and to investigate the clinical potential for replacing the manual registration with the automatic registration. Registrations and analysis were performed for 30 prostate cancer patients treated with IGRT using a Ni‐Ti prostate stent as a fiducial marker. The comparison included computing translational and rotational differences between the approaches, visual inspection, and computing the overlap of the CTV. The computed mean translational difference was 1.65, 1.60, and 1.80 mm and the computed mean rotational difference was 1.51°, 3.93°, and 2.09° in the superior/inferior, anterior/posterior, and medial/lateral direction, respectively. The sensitivity of overlap was 87%. The results demonstrate that the automatic registration approach performs registrations comparable to the manual registration.PACS number(s): 87.57.nj, 87.61.‐c, 87.57.Q‐, 87.56.J‐

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Section: Discussionmentioning

confidence: 99%

Comparison of manual and automatic MR‐CT registration for radiotherapy of prostate cancer

Korsager

Carl

Østergaard

2016

J Applied Clin Med Phys

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“…(1), ranged from 0.4 to 0.8 mm, which is within the acceptable margins of error for radiation treatment planning for the prostate, liver, and pancreas. [5][6][7][8]31,32 Figure 2(c) shows the reproducibility of the six markers individually as well as all six markers combined. The combined approach was used to report reproducibility in vivo.…”

Section: Ex Vivo Reproducibilitymentioning

confidence: 99%

In vivo reproducibility of robotic probe placement for a novel ultrasound-guided radiation therapy system

et al. 2014

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Abstract. Ultrasound can provide real-time image guidance of radiation therapy, but the probe-induced tissue deformations cause local deviations from the treatment plan. If placed during treatment planning, the probe causes streak artifacts in required computed tomography (CT) images. To overcome these challenges, we propose robot-assisted placement of an ultrasound probe, followed by replacement with a geometrically identical, CT-compatible model probe. In vivo reproducibility was investigated by implanting a canine prostate, liver, and pancreas with three 2.38-mm spherical markers in each organ. The real probe was placed to visualize the markers and subsequently replaced with the model probe. Each probe was automatically removed and returned to the same position or force. Under position control, the median three-dimensional reproducibility of marker positions was 0.6 to 0.7 mm, 0.3 to 0.6 mm, and 1.1 to 1.6 mm in the prostate, liver, and pancreas, respectively. Reproducibility was worse under force control. Probe substitution errors were smallest for the prostate (0.2 to 0.6 mm) and larger for the liver and pancreas (4.1 to 6.3 mm), where force control generally produced larger errors than position control. Results indicate that position control is better than force control for this application, and the robotic approach has potential, particularly for relatively constrained organs and reproducibility errors that are smaller than established treatment margins.

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“…Although the adoption of emerging technologies seems to be intuitive to those performing the treatment 53 , the current paucity of high level evidence in terms of tumour control or toxicity benefits has left many administrative bodies with substantially less enthusiasm in supporting its use. Indeed, it is crucial that implementation of new technology is done in a controlled manner, as inappropriate implementation of techniques based on assumptions rather than proven performance may be detrimental 54 . Physics is very much the key to much of this technology moving forward, both in conventional practice and in the research arena.…”

Section: Where Is the Physicist In All Of This?mentioning

confidence: 99%

Radiation therapy of prostate cancer: rationale, pitfalls and the continuing prospect of success forged by medical physics

2009

Australas. Phys. Eng. Sci. Med.

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Radiation therapy aimed at curing prostate cancer forms a considerable workload in most contemporary radiation oncology departments. The wide range of currently available therapeutic strategies for this cancer and their increasing complexity further increases the impact these patients have within the treating unit. Grounded in basic anatomy, physiology and pathology, the rationale for the division of prostate cancers into different prognostic and therapeutic groups is discussed, and put into clinical context using the current research evidence base. Weaknesses in this evidence base are highlighted in relation to areas directly impacted on by the work of medical physics.

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Conformal Arc Radiotherapy for Prostate Cancer: Increased Biochemical Failure in Patients With Distended Rectum on the Planning Computed Tomogram Despite Image Guidance by Implanted Markers

Cited by 155 publications

References 27 publications

Comparison of manual and automatic MR‐CT registration for radiotherapy of prostate cancer

Comparison of manual and automatic MR‐CT registration for radiotherapy of prostate cancer

In vivo reproducibility of robotic probe placement for a novel ultrasound-guided radiation therapy system

Radiation therapy of prostate cancer: rationale, pitfalls and the continuing prospect of success forged by medical physics

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