2015
DOI: 10.1039/c5mb00194c
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Conformational analysis on the wild type and mutated forms of human ORF1p: a molecular dynamics study

Abstract: The protein ORF1p, encoded by the LINE-1 retrotransposon, is responsible for the packaging and transposition of its RNA transcript and is reported to be involved in various genetic disorders. The three domains of ORF1p co-ordinate together to facilitate the transposition, and the mechanism of nucleic acid binding is not yet clear. The C-terminal domain of ORF1p adopts a lifted, twisted or rested state, which is regulated by several inter- and intra-domain interactions that are explored in this study. The resid… Show more

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Cited by 6 publications
(1 citation statement)
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“…Yet, MD has offered opportunities in other areas to investigate complex molecular behaviour where conformational changes of ligands play a pivotal role in a time-dependent manner and therefore have already been applied to LPS-like ligands. 4,12,[54][55][56][57][58]…”
Section: Speciesmentioning
confidence: 99%
“…Yet, MD has offered opportunities in other areas to investigate complex molecular behaviour where conformational changes of ligands play a pivotal role in a time-dependent manner and therefore have already been applied to LPS-like ligands. 4,12,[54][55][56][57][58]…”
Section: Speciesmentioning
confidence: 99%