1985
DOI: 10.1016/0197-4580(85)90010-7
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Conformational changes in muscarinic receptors may produce diminished cholinergic neurotransmission and memory deficits in aged rats

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Cited by 80 publications
(16 citation statements)
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“…For instance, aged rats that display memory deficits often display correlated decreases in hippocampal ACh markers (Lippa et al 1980(Lippa et al , 1985Sherman et al 1981;Ikegami 1994;Scali et al 1994;Aubert et al 1995;Baxter et al 1999b). Chronic dietary restriction of choline (Nakamura et al 2001) or vitamin A (Cocco et al 2002), and chronic alcohol consumption (Arendt et al 1990;Melis et al 1996) produce correlated deficits in memory and hippocampal ACh.…”
Section: Hippocampal Ach Activity Is Correlated With Memorymentioning
confidence: 99%
“…For instance, aged rats that display memory deficits often display correlated decreases in hippocampal ACh markers (Lippa et al 1980(Lippa et al , 1985Sherman et al 1981;Ikegami 1994;Scali et al 1994;Aubert et al 1995;Baxter et al 1999b). Chronic dietary restriction of choline (Nakamura et al 2001) or vitamin A (Cocco et al 2002), and chronic alcohol consumption (Arendt et al 1990;Melis et al 1996) produce correlated deficits in memory and hippocampal ACh.…”
Section: Hippocampal Ach Activity Is Correlated With Memorymentioning
confidence: 99%
“…[7][8][9]. Electrophysiological experiments in the hippocampus of old rats showed impairment in neuronal response to local application of ACh (but not of glutamate) without consistent changes in receptor number (1). Chronic treatment with the cholinergic agonist or antagonist induced changes in receptor number (down-and up-regulation, respectively) in the frontal cortex ofyoung but not aged mice (34).…”
mentioning
confidence: 97%
“…Although the aging process seems to impinge on several neurotransmitter systems, special emphasis has been placed on the role of the cortical cholinergic innervation in geriatric memory dysfunction (6). Studies in rodents have shown a consistent decline in cortical acetylcholine (ACh) synthesis and release during aging (7-9), although little or no change occurs in cortical choline acetyltransferase activity (1,8,6,10). Further, the cholinergic basal forebrain neurons that project to the cortex undergo an age-related decrease in size though their number is apparently not diminished (11).…”
mentioning
confidence: 99%
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