Confounding risk factors and preventative measures driving nephrolithiasis global makeup

Shin, Samuel; Srivastava, Aneil; Alli, Nazira A; Bandyopadhyay, Bidhan C.

doi:10.5527/wjn.v7.i7.129

Cited by 29 publications

(28 citation statements)

References 72 publications

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“…The composition of the patient's diet is one of the more important risk factors for pediatric and adult urolithiasis [8,20,21]. The nutrients involved in the development of kidney stones are many, including sodium, oxalate, calcium, phosphate, magnesium, potassium, animal protein, sugars, citrate, and possibly others [20]. Consequently, whenever applicable, dietary interventions are used to combat stone formation.…”

Section: Causes and Prognosis Of Infantile Urolithiasismentioning

confidence: 99%

Infantile urolithiasis

Penido

Alon

2021

Pediatr Nephrol

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Section: Causes and Prognosis Of Infantile Urolithiasismentioning

confidence: 99%

Infantile urolithiasis

Penido

Alon

2021

Pediatr Nephrol

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“…Over the last decades, urolithiasis incidence has been increasing worldwide at an alarming rate [3]. Several factors such as age, gender, race, nutrition, daily water intake, climate, geography, physical activity and Body Mass Index (BMI) play a key role in urolithiasis pathogenesis [4].…”

Section: Introductionmentioning

confidence: 99%

Eating Habits among Lithiasic Patients in Kinshasa, the Democratic Republic of Congo

Diangienda¹,

Moningo²,

Mayindu³

et al. 2021

OJU

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Introduction: Worldwide, the incidence of kidney stones has been progressively increasing. Various factors can influence the risk of stone formation, including lifestyle and eating habits. The dietary investigation is a standard of care in patients with urolithiasis. The objectives of this study were to determine the dietary habits of lithiasis patients in the city of Kinshasa and to investigate the association between dietary habits and the composition of the stones. Material and methods: From January 2017 to September 2019, 85 patients attending 8 hospitals participated in the nutrition survey. Various foods commonly consumed in the Democratic Republic of Congo were categorized based on their composition: foods rich in animal proteins, foods rich in calcium, foods high in sugar, foods high in oxalate, and various vegetables and fruits. We also investigated daily water intake. The composition of the collected stones was analyzed by infrared spectrophotometry. Results: The mean (SD) age of patients was 47.1 (14.0) years, 63.5% of patients were males, 75.3% of the patients had stones located in the upper urinary tract, and 7.1% were undernourished. Most of patients consumed vegetables (77.6%), animal proteins (62.4%), and foods rich in oxalate (58.8%). The daily water intake was less than 1500 mL in more than half of the patients (68.2%). Major anhydrous uric acid stones were associated with a high body mass index (p = 0.025). Male patients with a high oxalate diet had more calcium oxalate stones (64.3%) compared to other types of stones (p = 0.041). Conclusion: High consumptions of vegetables and low water intake were linked to the formation of cal-How to cite this paper:

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“…The disease has been described to have accompanying severe pain, and its treatment is a financial burden on the healthcare system. Various risk factors can exacerbate the formation or recurrence of calcium nephrolithiasis (3). As the most common metabolic abnormality, hyperoxaluria increases the risk of calcium stone formation (2,4).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Oxalobacter formigenes Colonization in Patients with Calcium Oxalate Renal Stones in Comparison with Healthy People in Qom: A Case-Control Study

et al. 2021

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Background: Urinary stones are a major problem world, and their incidence has increased significantly in recent years. Objectives: This study aimed to develop a simple and rapid molecular method based on PCR and qPCR assays to detect Oxalobacter formigenes (which causes oxalate degradation in intestines) in fecal samples of healthy volunteers and patients with calcium oxalate nephrolithiasis, and determine the amount of urinary oxalate in the two groups. Methods: This study was performed on urine and fecal samples of 73 patients with kidney stones and 52 healthy individuals. After DNA extraction, PCR and qPCR assays were performed on two gene regions of Oxalobacter formigenes, OXC, and FRC. Also, urine oxalate was measured in the study population using biochemical methods. Results: We found that the presence of Oxalobacter formigenes could reduce the risk of kidney stones and calcium oxalate stones. In fact, both FRC and OXC genes were involved in the diagnosis of Oxalobacter formigenes; however, the results based on the FRC gene showed higher efficiency. In addition, the presence or absence of stones did not affect the amount of urinary excretion of oxalate, rather it is affected by diet. Conclusions: Molecular identification of Oxalobacter formigenes by PCR and qPCR assays allows rapid, specific, and reproducible detection in fecal samples, which also allows immediate processing of these samples in clinical conditions.

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Confounding risk factors and preventative measures driving nephrolithiasis global makeup

Cited by 29 publications

References 72 publications

Infantile urolithiasis

Infantile urolithiasis

Eating Habits among Lithiasic Patients in Kinshasa, the Democratic Republic of Congo

The Effect of Oxalobacter formigenes Colonization in Patients with Calcium Oxalate Renal Stones in Comparison with Healthy People in Qom: A Case-Control Study

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