1998
DOI: 10.1016/s0065-2776(08)60405-8
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Confrontation between Intracellular Bacteria and the Immune System

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Cited by 171 publications
(157 citation statements)
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References 675 publications
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“…cdT cells produce IFN-c [38] and anti-inflammatory cytokines such as IL-10 [6,15] that inhibit the production of pro-inflammatory mediators including IL-1, TNF-a, and IL-8 produced by inflammatory cells within affected tissues. Through such indirect mechanisms, cdT cells may prevent the recruitment of PMN to inflammatory sites, suppress oxidative burst and degranulation, and reduce PMN-mediated tissue injury [7,8].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…cdT cells produce IFN-c [38] and anti-inflammatory cytokines such as IL-10 [6,15] that inhibit the production of pro-inflammatory mediators including IL-1, TNF-a, and IL-8 produced by inflammatory cells within affected tissues. Through such indirect mechanisms, cdT cells may prevent the recruitment of PMN to inflammatory sites, suppress oxidative burst and degranulation, and reduce PMN-mediated tissue injury [7,8].…”
Section: Discussionmentioning
confidence: 99%
“…The regulatory function of cdT cells is mediated through the production of cytokines such as IFN-c, IL-10, and TNF-a as well as through direct cytotoxicity towards target cells, resulting in the resolution of inflammatory processes [6][7][8]. Accumulation of cdT cells is seen in sites of inflammation that are associated with intracellular bacterial, viral, and parasitic infections.…”
Section: Introductionmentioning
confidence: 99%
“…In this study, addition of B. pseudomallei to naive spleen cells resulted in the rapid activation of DX5 ϩ / NK1.1 ϩ cells for IFN-␥ production. Recent evidence suggests that several distinct T cell populations also have the potential to make IFN-␥ with an intermediate kinetics between the rapid NK cell response and the acquisition of acquired immunity (24,25). These include NK T cells (26,27), ␥␦ T cells (11,28), CD4 Ϫ CD8 Ϫ (29), or CD8 ϩ T cells responding to microbial products presented via the CD1 system (30,31) and other CD8 ϩ T cells triggered via recognition of N-formylated bacterial peptides via the H2-M3 Ag presentation system (32).…”
Section: Discussionmentioning
confidence: 99%
“…Most immunocompetent individuals infected with tubercle bacilli do not develop disease, which indicates the important role of the specific immune response in restricting mycobacterial growth (26). The protective immune response comprises both CD4 and CD8 T cells and perhaps unconventional T cell populations such as ␥/␦ T cells (27).…”
Section: Discussionmentioning
confidence: 99%