Purpose: This examined the impact of disruptions in information flow, job satisfaction, lack of access to support and communication, motivational factors, social isolation, and working remotely on job performance. The study tested the mediation effect of job satisfaction on the relationship between disruptions in information flow, lack of access to support and communication, motivational factors, social isolation, and working remotely and job performance. Results: The result showed that there was a positive and significant relationship between job satisfaction and job performance with beta = 0.531, T-value = 4.980, and P-value = 0.000. There was also a positive and significant relationship between social isolation and job performance with beta = 0. 217, T-value = 2.101, and P-value = 0.036. but there was a negative and significant relationship between working remotely and job performance with beta = -0.281, T-value = 2.744, and P-value = 0.006. The mediating effect test showed that job satisfaction mediated the relationship between disruptions in information flow and job performance with a significant level = of 0.000. also, Job satisfaction mediated the relationship between working remotely and job performance with a considerable level = of 0.021. The study employed the direct effect test and found no relationship between disruptions in information flow and job performance. Further, job satisfaction did not mediate the relationship between motivational factors, social isolation, lack of access to support and communication and job performance.