Congenital acute lymphoblastic leukemia: Report of a case with unusual immunophenotype

Garewal, G.; Marwaha, Ram Kumar; Ray, Ruma; Singh, Namrata; Gupta, Ajay; Sarode, V.R.

doi:10.1002/ajh.2830440215

Cited by 8 publications

(3 citation statements)

References 7 publications

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Section: Review Of the Literature (Including The Dutch Patients) (Tabmentioning

confidence: 99%

“…A Medline search for English language papers on congenital and neonatal leukaemia between 1975 and 2000 was carried out. A total of 102 patients with congenital leukaemia, as defined by the diagnostic criteria stated above, were identified (Abe et al , 1983; Allan et al , 1989; Badhe & Sane, 1992; Bastard et al , 1985; Benedict et al , 1979; Bernstein et al , 1984; Bernstein et al , 1987; Brissette et al , 1996; Campbell et al , 1997; Carney et al , 1992; Chu et al , 1983; Clark et al , 1984; Dinulos et al , 1997; Djernes et al , 1976; Embon et al , 1995; Fernandez et al , 1999; Francis et al , 1989; Fugazza et al , 1992; Gale & Toledano, 1984; Gale et al , 1986; Garewal et al , 1993; Gilgenkrantz et al , 1983; Gottesfeld et al , 1989; Gray et al , 1986; Hagemeijer et al , 1981; Hanada et al , 1991; Hara et al , 1984; Hayashi et al , 1985; Hazani et al , 1993; Heikinheimo et al , 1994; Huret et al , 1993; Irwin & Campbell, 1978; Isaacs, 1987; Jadhav et al , 1988; Kojima et al , 1989; Kurosawa et al , 1987; Kushwaha et al , 1977; Lampkin et al , 1985; Las‐Heras et al , 1986; Lasson & Goos, 1981; Liang et al , 1986; Liang et al , 1993; Lilleyman, 1980; Matamoros et al , 1994; Mayer et al , 1995; McCoy et al , 1995; Monpoux et al , 1996; Mori et al , 1997; Muchi et al , 1985; Odom & Gordon, 1984; Ohyashiki et al , 1988; Raney et al , 1979; Rechavi et al , 1988; Resnik & Brod, 1993; Ridge et al , 1995; Sainati et al , 1996; Sait et al , 1988; Seo et al , 1986; Shah et al , 1984; Shimizu et al , 1987; Shimizu et al , 1989; Shitara et al , 1992; Silberstein et al , 1979; Simon et al , 1984; Sippe, 1981; Spier et al ...…”

Section: Review Of the Literature (Including The Dutch Patients) (Tabmentioning

confidence: 99%

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Congenital leukaemia: the Dutch experience and review of the literature

et al. 2002

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Summary. We reviewed Dutch patients and those described in the literature with congenital leukaemia in the past 25 years, with the intention to obtain an overview of the characteristics of this rare disease. Among the 117 patients reviewed, acute myeloid leukaemia (AML) was more frequent (64%) than acute lymphoblastic leukaemia (ALL, 21%). Most patients had a high leukaemic cell load with hepatosplenomegaly, leukaemia cutis and hyperleucocytosis. Cytogenetic abnormalities were found in the majority of the patients tested (72%); 11q23 abnormalities were found in less than half of them (42%). The probability of overall survival at 24 months was only 23%. When congenital AML and ALL were compared, clinical characteristics and overall survival were not significantly different. However, in patients at risk, the probability of event-free survival (EFS) and disease-free survival (DFS) were significantly higher in AML than in ALL, 43% versus 13% and 68% versus 0% respectively. Among the congenital AML cases, six spontaneous remissions have been described. In conclusion, the clinical characteristics of congenital leukaemia differ from those of leukaemia in older children and prognosis is generally poor. Once complete remission is achieved, patients with AML fare better than those with ALL. Chemotherapy for congenital leukaemia needs improvement to increase the sustained remission rate.

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Section: Review Of the Literature (Including The Dutch Patients) (Tabmentioning

confidence: 99%

Section: Review Of the Literature (Including The Dutch Patients) (Tabmentioning

confidence: 99%

Congenital leukaemia: the Dutch experience and review of the literature

et al. 2002

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“…7 per million live births (Bader & Miller, 1979) or 1% of all childhood leukaemias (Sansone et al, 1989) and this rarity has hampered the precise characterization of the blasts. Most congenital leukaemias are of monocytic origin (Darbyshire et al, 1985), but the existence of a small number of cases with lymphoid (Carney et al, 1992;Garewal et al, 1993) 2 . 2 n t n t CD3 0 .…”

Section: Discussionmentioning

confidence: 99%

Congenital leukaemia with a mixed phenotype of megakaryoblasts and erythroblasts: a case report and characterization of the blasts

et al. 1997

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Summary. We present a congenital leukaemia with a mixed phenotype of megakaryoblasts and erythroblasts. A newborn male with exopthalmus and multiple skin nodules, had bone marrow blasts which expressed CD41b, CD42b, glycophorin-A and haemoglobin, but monocyte or lymphoid markers were negative. The patient achieved a complete remission with chemotherapy. Blasts cultured for a few months expressed erythroid markers but lost the megakaryocytic phenotype, although addition of phorbol ester induced the latter phenotype. Spontaneous colony formation was observed in semi-solid culture and the number of colonies was increased by erythropoietin. Detailed studies further indicated the heterogeneity of congenital leukaemia.

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Immunophenotyping of congenital leukemia

1995

Cytometry

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Congenital leukemia is a rare but well‐documented disease in which a leukemic process is detected at birth or very shortly thereafter. An estimated 175–200 reports of congenital leukemia have appeared in the literature. The majority of the cases reported have not undergone thorough immunophenotyping, but rather have been assigned lineage based on cytochemical and morphological studies. Historically, a large proportion of congenital leukemias have been thought to be of the myeloid lineage, in contrast to pediatric leukemias in general, which are primarily lymphoid. The precise proportions of the lineage assignments may be distorted by the inclusion of cases of transient myeloproliferative disorders (TMD) as congenital leukemia. The immunophenotyping data available to date suggest that congenital leukemias are phenotypically heterogeneous, lacking any common distinguishing markers. The prognosis for congenital leukemias is usually poor if leukemoid reactive processes, such as TMD, are carefully excluded. © 1995 Wiley‐Liss, Inc.

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Congenital acute lymphoblastic leukemia: Report of a case with unusual immunophenotype

Cited by 8 publications

References 7 publications

Congenital leukaemia: the Dutch experience and review of the literature

Congenital leukaemia: the Dutch experience and review of the literature

Congenital leukaemia with a mixed phenotype of megakaryoblasts and erythroblasts: a case report and characterization of the blasts

Immunophenotyping of congenital leukemia

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