Congenital cytomegalovirus infection diagnostics and management

Pinninti, Swetha; Boppana, Suresh B.

doi:10.1097/qco.0000000000000874

Cited by 10 publications

(22 citation statements)

References 57 publications

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“…More than half of the congenitally infected infants identified by the newly implemented universal screening (30 of 54; 55.6%) would have been ‘missed’ by our previous targeted screening approach. This finding is in agreement with the general recognition that in the absence of universal screening, most cCMV cases remain undiagnosed 7 , 9 , 11 . Of the 30 well-appearing infants who were identified and consequently further evaluated because of universal screening, one had intracranial involvement, leading to early administration of antiviral treatment.…”

Section: Discussionsupporting

confidence: 91%

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Implementation of pooled saliva tests for universal screening of cCMV infection

Merav,

Ofek Shlomai,

Oiknine-Djian

et al. 2024

Nat Med

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Congenital cytomegalovirus (cCMV) is the most common intrauterine infection, leading to neurodevelopmental disabilities. Universal newborn infant screening of cCMV has been increasingly advocated. In the absence of a high-throughput screening test, which can identify all infected newborn infants, the development of an accurate and efficient testing strategy has remained an ongoing challenge. Here we assessed the implementation of pooled saliva polymerase chain reaction (PCR) tests for universal screening of cCMV, in two hospitals of Jerusalem from April 2022 through April 2023. During the 13-month study period, 15,805 infants (93.6% of all live newborn infants) were screened for cCMV using the pooled approach that has since become our routine screening method. The empirical efficiency of the pooling was six (number of tested newborn infants per test), thereby sparing 83% of the saliva tests. Only a minor 3.05 PCR cycle loss of sensitivity was observed for the pooled testing, in accordance with the theoretical prediction for an eight-sample pool. cCMV was identified in 54 newborn infants, with a birth prevalence of 3.4 per 1,000; 55.6% of infants identified with cCMV were asymptomatic at birth and would not have been otherwise targeted for screening. The study demonstrates the wide feasibility and benefits of pooled saliva testing as an efficient, cost-sparing and sensitive approach for universal screening of cCMV.

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Section: Discussionsupporting

confidence: 91%

“…The development of an efficient testing strategy to enhance universal screening of cCMV is recognized as a high priority goal 9 , 11 . In this study, we report on the implementation of eight-sample pooling of saliva samples for universal screening of cCMV.…”

Section: Discussionmentioning

confidence: 99%

Implementation of pooled saliva tests for universal screening of cCMV infection

Merav,

Ofek Shlomai,

Oiknine-Djian

et al. 2024

Nat Med

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“…Research conducted by Rendiana (2015) shows that there is a positive relationship for the relationship between efficiency and Return on Asset in banking. Operational efficiency affects financial performance as measured using the ROA ratio (Pinninti et. al., 2022).…”

Section:  H2 Intellectual Capital Has a Positive Effect On Bank Effi...mentioning

confidence: 99%

Does bank efficiency mediate the effect of intellectual capital on banking profitability in Indonesia?

Ni Komang Juliantari,

Luh Gede Sri Artini

2023

World J. Adv. Res. Rev.

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This study aims to obtain empirical evidence regarding the role of bank efficiency in mediating the relationship between intellectual capital and profitability. The population in this study is the conventional banking sector which is listed on the Indonesia Stock Exchange from 2018 to 2022. Sampling was carried out by purposive sampling with a total sample of 115 observations. The analysis technique in this study uses SPSS (Statistical Package for the Social Sciences). The results of the analysis provide evidence that intellectual capital has a positive effect on banking profitability, intellectual capital has a positive effect on the efficiency of banking sector companies, bank efficiency has a positive effect on the profitability of banking sector companies, and bank efficiency mediates partially (complementary partial mediation) on the effect of intellectual capital on banking profitability.

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“…After initial infection, typically acquired through close contact with body fluids such as saliva or urine, the virus establishes a latent state within specific cells of the host's immune system, including monocytes and macrophages [3]. While the immune response can control active viral replication, the virus remains latent, ready for reactivation under conditions of immunosuppression or other triggers [4].…”

Section: Introductionmentioning

confidence: 99%

“…In developed countries, CMV infection during pregnancy is relatively common [1], with a range of potential fetal outcomes. These outcomes vary widely, from asymptomatic infection to the development of severe fetal abnormalities affecting multiple organ systems [1,4]. Notably, congenital CMV infection is recognized as the most common viral cause of congenital disability worldwide, with profound implications for long-term health outcomes [4].…”

Section: Introductionmentioning

confidence: 99%

Congenital cytomegalovirus infection: A narrative review

Christina Nanou,

Maria Tigka,

Dimitra Metallinou

2024

World J. Adv. Res. Rev.

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Cytomegalovirus (CMV) infection poses significant health risks, particularly for vulnerable populations including fetuses infected in utero, premature infants, and immunocompromised individuals. CMV infection is the most prevalent cause of congenital infection, affecting approximately 0.5% to 2% of all live births worldwide. Congenital transmission during pregnancy is a major concern, with a variety of fetal and neonatal outcomes ranging from asymptomatic infection to severe abnormalities, including sensorineural hearing loss, visual impairment, various neurological sequelae, growth retardation and potentially fatal consequences. Congenital transmission of CMV from mother to fetus can occur through primary infection, or reactivation of a previous infection. Diagnosis involves imaging techniques and invasive procedures to detect CMV DNA. Antiviral medications have limited data for use during pregnancy, while ganciclovir or valganciclovir demonstrates potential benefits in neonates with symptomatic disease. Routine antenatal screening is not yet recommended, but serological testing may be warranted in specific circumstances. Preventive measures focus on simple hygiene practices. Childbirth and breastfeeding present potential risks of CMV transmission, highlighting the importance of close monitoring and informed decision-making. This narrative review aims to provide a comprehensive summary of the epidemiology, transmission patterns, clinical manifestations, diagnostic approaches, treatment modalities, screening methods, preventive measures, and breastfeeding considerations related to CMV infection. This knowledge is essential for healthcare professionals to effectively manage CMV infection and improve outcomes for affected individuals and their families.

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Congenital cytomegalovirus infection diagnostics and management

Cited by 10 publications

References 57 publications

Implementation of pooled saliva tests for universal screening of cCMV infection

Implementation of pooled saliva tests for universal screening of cCMV infection

Does bank efficiency mediate the effect of intellectual capital on banking profitability in Indonesia?

Congenital cytomegalovirus infection: A narrative review

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