Congenital malformations among liveborn infants with trisomies 18 and 13

Abstract

Trisomy 18 and trisomy 13 are associated with serious and/or fatal birth defects, with death frequently occurring in the first month of life. Previous studies are limited by small samples and are dated. This study characterized the comorbid birth defects associated with trisomy 18 and trisomy 13 among US liveborn infants using the Healthcare Cost and Utilization Project's Kids' Inpatient Database and Nationwide Inpatient Sample, two large, current and nationally representative databases. The occurrence of 39 commonly reported comorbid birth defects among infants with trisomies 18 and 13 was compared to the occurrence of malformations among newborns without trisomies. The prevalences of trisomy 18 and 13 were 1.29/10,000 and 0.85/10,000 live births, respectively. Among infants with trisomy 18, 61% were female, 45.4% with heart defects. Among those with trisomy 13, 53% were female, 38.4% had heart defects, 24.5% had orofacial anomalies, and 11.2% had central nervous system abnormalities. More than half of the newborns with both conditions died prior to discharge. This updated information can be used to inform clinical decision‐making and may help providers better prepare families for infants with trisomies. © 2006 Wiley‐Liss, Inc.

Polymelia and polydactyly in White Stork (Ciconia ciconia)

“…Polydactyly may occur due to similar reasons causing polymelia. 12 Polydactyly was reported so far on Vaux's Swift Chaetura vauxi, 13 screech owls Otis asio and pigeons, 14 as well. We report polymelia and polydactyly in an immature White Stork (Ciconia ciconia).…”

Özofagus atrezisi ve meningosel birlikteliği olan Edward’s sendromu olgusu

“…In surviving infants, mental retardation is observed which is more severe in girls (4). The syndrome is reported to be more frequent in girls (5).…”

A rare case report of unusual presentation of Edward’s syndrome (trisomy 18)

“…2 There is a 3:1 ratio in the prevalence of females to males, as most male infants with this disease die during pregnancy. 3 This syndrome affects multiple organs, leading to neurological, cardiac, pulmonary, gastrointestinal, musculoskeletal manifestations. This case is reported due to its unusual presentation and rarity of syndrome in Indian scenario.…”