Congenital syphilis – a public health problem only in Brazil?

Passos, Mrl

doi:10.1111/1471-0528.15318

Cited by 4 publications

(4 citation statements)

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“…30 In Brazil, congenital syphilis cases have been observed since 2010, and this resurgence has been linked to the low level of education and to difficulties in access to care. 31 By contrast, in Bulgaria and Romania, the two European countries with the largest reported numbers of congenital syphilis, there has been a decrease in the number of cases in recent years. 26 Given the resurgence of congenital syphilis in Reunion Island, it is now recommended to perform a second syphilis serology between the 22 nd and 32 nd week of amenorrhea.…”

Section: Discussionmentioning

confidence: 99%

“…In Japan, the incidence began to increase in 2012, reaching 1.4 cases per 100 000 live births in 2016 30 . In Brazil, congenital syphilis cases have been observed since 2010, and this resurgence has been linked to the low level of education and to difficulties in access to care 31 . By contrast, in Bulgaria and Romania, the two European countries with the largest reported numbers of congenital syphilis, there has been a decrease in the number of cases in recent years 26 .…”

Section: Discussionmentioning

confidence: 99%

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High prevalence of syphilis in women, minors and precarious patients: a cross‐sectional study in a Reunion Island sexually transmitted infection clinic, 2017–2020

Delfosse¹,

Bouscaren

Dupin

et al. 2021

Acad Dermatol Venereol

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Background Syphilis is a sexually transmitted infection (STI) with a global prevalence estimated at 0.5% in 2012.Syphilis has been on the rise among men who have sex with men (MSM) in high-income countries and remains at endemic levels in low-and middle-income countries. This trend, however, has not been observed in Reunion Island.Objectives To determine the prevalence, clinical characteristics and risk factors of syphilis in at-risk patients visiting the South Reunion STI clinic in Reunion Island.Methods This monocentric cross-sectional study included all patients who visited our STI clinic between 2017 and 2020. Syphilis serology was performed on all included patients, and data were collected using a standardized selfadministered questionnaire. ResultsOver the 3-year study period, 2593 patients were enrolled. The prevalence of syphilis was 7.52% (n = 195, 95% CI, 6.50-8.65%) in the overall study population, 11.76% (n = 18, 95% CI, 6.97-18.59%) in minors (aged under 18 years) and 36.36% (n = 16, 95% CI, 21-59%) in pregnant women. The risk factors identified in multivariate analysis were being female [adjusted Prevalence Ratio (aPR) 1.85, 95% CI, 1.10-3.11], being MSM (aPR 2.87, 95% CI, 1.71-4.80), being aged under 18 years (aPR 3.54, 95% CI, 1.90-6.57), living in precarious conditions [aPR 3.12, 95% CI, 2.11-4.62] and being born in Reunion Island (aPR 2.43, 95% CI, 1.42-4.13). The clinical presentation was heterogeneous (plaques and papules, chancre, atypical ulcerations, multiple ulcerations, condyloma lata, etc.).Conclusions These findings suggest a high prevalence of syphilis in at-risk patients visiting our STI clinic. Unlike the situation in other high-income countries, the people most at risk of syphilis in Reunion Island are local-born residents, minors, women and precarious patients. This is a source of concern, especially given the risk of resurgence of congenital syphilis on the island.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

High prevalence of syphilis in women, minors and precarious patients: a cross‐sectional study in a Reunion Island sexually transmitted infection clinic, 2017–2020

Delfosse¹,

Bouscaren

Dupin

et al. 2021

Acad Dermatol Venereol

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“…These include that dual EMTCT of both HIV and syphilis or triple EMTCT of HIV, syphilis and hepatitis B, WHO country validation of EMTCT of syphilis and HIV, set up a CS case review board and a National Day to Combat Syphilis and Congenital Syphilis and so on. 27,28,[66][67][68][69][70][71][72][73][74][75][76][77][78][79][80] In 2010, China made a commitment to the dual EMTCT of HIV and syphilis, providing an important opportunity for the MTCT of syphilis to be prioritized in policy and resource allocation at national and subnational levels. 66 A workshop, co-convened by WHO and partners, was held in June 2011 for six Sub-Saharan African countries with a strong interest in dual elimination to support the development of action plans addressing the opportunities and urgency of joint program planning.…”

Section: Maternal Syphilis Screening Diagnosis and Treatmentmentioning

confidence: 99%

“…78 In Brazil, a National Day to Combat Syphilis and Congenital Syphilis (third Saturday in October) was designated to further raise public awareness of the problem and to promote educational activities on sexuality and sexually transmitted infections. 79 Several tools, such as antenatal-care syphilis testing recommendations; rapid HIV and syphilis test interim guidance; current and projected use of BPG in maternal syphilis; syphilis treatment guidelines; CS case definition; staff training on BPG administration; and penicillin desensitization protocols may aid the screening, treatment, and elimination of CS. 64 The country validation of EMTCT of syphilis and HIV launched by the WHO may greatly speed up the EMTCT of syphilis action and decrease CS prevalence.…”

Section: Maternal Syphilis Screening Diagnosis and Treatmentmentioning

confidence: 99%

Elimination of Mother-to-child Transmission of Syphilis: Challenge and Solution

Fan

Wang²,

Wang

2019

Maternal-Fetal Medicine

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Congenital syphilis (CS) is a significant public health problem worldwide. The majority of cases of CS are caused by in utero transmission. The World Health Organization launched the global elimination of CS initiative with the goal of reducing mother-to-child transmission of syphilis. The risk for CS is mainly related to three factors: (1) high maternal prevalence, (2) low coverage of antenatal care services, and (3) treatment failure. The long-acting penicillin preparations such as benzathine penicillin G are the preferred therapies for maternal syphilis. There are several challenges in preventing CS from both pregnant women and their health care providers. These problems include that prenatal care lack or delay, syphilis management flaws from health care providers, lacks of basic information, and awareness about maternal syphilis and CS by public. Many efforts have been made to solve the problems. These include that dual elimination of mother-to-child transmission (EMTCT) of both human immunodeficiency virus (HIV) and syphilis or triple EMTCT of HIV, syphilis and hepatitis B, World Health Organization country validation of EMTCT of syphilis and HIV, set up a CS case review board and a National Day to combat syphilis and CS.

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Syphilis among HIV serodiscordant partners associated with Human Papillomavirus Infection in a bisexual man

Boldrini

Caldas

Almeida

et al. 2020

J Bras Doenças Sex Transm

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Introduction: Syphilis and HIV infections are sexually transmitted infections whose diagnosis and treatment contribute toward preventing congenital transmission. Objective: To report a case of three sexually transmitted infections detected in a male partner during Couple Consultation and syphilis in the female partner during prenatal care. Case report: A 34-year-old black female G2P1 pregnant woman was referred to an outpatient clinic of sexually transmitted infections in Vitória, Brazil, reporting a 30-day evolution of painless papular lesions in the external genitalia, suggestive of condylomata lata. Nontreponemal tests were positive for syphilis and negative for HIV. The husband reported unprotected receptive anal intercourse and possessed anal condylomatous lesions and perianal condylomata lata. He was positive for both HIV and syphilis. Histopathological findings showed low-grade HPV lesions and the PCR test found 16, 39, and 53 HPV subtypes. Treatment with benzathine penicillin G was successful for both partners. Conclusion: This study emphasizes the need for Couple Consultation during pregnancy to identify and treat possible sexually transmitted infections.

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Congenital syphilis – a public health problem only in Brazil?

Cited by 4 publications

References 0 publications

High prevalence of syphilis in women, minors and precarious patients: a cross‐sectional study in a Reunion Island sexually transmitted infection clinic, 2017–2020

High prevalence of syphilis in women, minors and precarious patients: a cross‐sectional study in a Reunion Island sexually transmitted infection clinic, 2017–2020

Elimination of Mother-to-child Transmission of Syphilis: Challenge and Solution

Syphilis among HIV serodiscordant partners associated with Human Papillomavirus Infection in a bisexual man

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