Congenital Syphilis

Robinson, R. C. V.

doi:10.1001/archderm.1969.01610230091019

Cited by 16 publications

(3 citation statements)

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“…These include multiple notching or serrated edges which were seen in five patients [63] pitted enamel hypoplasia of the upper central and lateral incisors and primary and secondary dental caries on numerous teeth [64]. Narrowing and a reduction of the dentinoenamel junction of the permanent incisors and first molars, with a reduction in the size of the crowns and constriction of mamelons, was also noted by Sarnat and Shaw [27].…”

Section: Differential Diagnosismentioning

confidence: 85%

Diagnosis of Mercurial Teeth in a Possible Case of Congenital Syphilis and Tuberculosis in a 19th Century Child Skeleton

Ioannou

Henneberg

et al. 2015

Journal of Anthropology

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Without the presence of “caries sicca,” “sabre shins,” and nodes/expansion of the long bones with superficial cavitation, differential diagnosis of venereal syphilis and tuberculosis (TB) may be difficult as various infections produce similar responses. However, congenital syphilis has distinctive features facilitating a diagnosis. A case study of remains of a juvenile European settler (probably male, 8–10 years old) (B70) buried in the 19th century and excavated in 2000 from the cemetery of the Anglican Church of St. Marys in South Australia is presented. B70 demonstrated that the two diseases might have been present in the same individual, congenital syphilis and TB. Widespread destruction of vertebral bodies and kyphosis-related rib deformations indicate advanced TB. Severe dental hypoplasia is limited to permanent incisors and first molars; there is pitting on the palate, periosteal reaction on the skull vault, and thinned clavicles. Dental signs are not limited to “screwdriver” central incisors and mulberry molars. Apical portions of the crowns of permanent upper, lower, central, and lateral incisors have multiple hypoplastic-disorganized defects; deciduous canines have severely hypoplastic crowns while possibly hypoplastic occlusal surfaces of lower deciduous second molars are largely destroyed by extensive caries. These dental abnormalities resemble teeth affected by mercurial treatment in congenital syphilitic patients as described by Hutchinson.

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Section: Differential Diagnosismentioning

confidence: 85%

Diagnosis of Mercurial Teeth in a Possible Case of Congenital Syphilis and Tuberculosis in a 19th Century Child Skeleton

Ioannou

Henneberg

et al. 2015

Journal of Anthropology

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“…As many as onefourth to one-third of patients older than 2 years have asymptomatic neurosyphilis (357). Symptomatic neurosyphilis develops rarely, with juvenile paresis developing in 1 to 5% of patients with congenital syphilis (278,357). The symptoms of juvenile paresis are usually more severe than those of acquired paresis, and the typical onset occurs in puberty.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Syphilis: Review with Emphasis on Clinical, Epidemiologic, and Some Biologic Features

1999

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SUMMARY Syphilis is a chronic disease with a waxing and waning course, the manifestations of which have been described for centuries. It occurs worldwide, and the incidence varies significantly with geographic location. Transmission is mainly by sexual contact. The causative organism, Treponema pallidum, was first described in 1905, but because of the inability to culture the organism and the limitations of direct microscopy, serologic testing is the mainstay of laboratory diagnosis. The disease has been arbitrarily divided into several stages. The primary stage is defined by a chancre at the site of inoculation. The secondary stage is characterized by a polymorphic rash, lymphadenopathy, and other systemic manifestations. A variable asymptomatic latent period follows, which for epidemiologic purposes is divided into early (<1 year) and late (>1 year) stages. The early stages (primary, secondary, and early latent) are potentially infectious. The tertiary stage is the most destructive and is marked by cardiovascular and neurologic sequelae and gummatous involvement of any organ system. Congenital infection may result in protean early or late manifestations. Unlike many other bacteria causing infectious diseases, the organism remains sensitive to penicillin, and this remains the mainstay of therapy.

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“…Los anticuerpos anticardiolipina de origen materno se catabolizan a un 50% de su nivel original al mes de nacimiento ya los 6 meses no deberán quedar rastros (12). Los anticuerpos treponémicos de origen materno deberán desaparecer a más tardar al a1"1o de evolución.…”

Section: Diagnostico Prenatalunclassified

Sífilis congénita

Montoya

1992

Iatreia

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Se discuten diversos aspectos de la sífilis congénita con énfasis en los siguientes: el hecho de que 60% de las madres que engendran niños sifilíticos no presentan evidencia clínica de la enfermedad; la necesidad de ordenar un mínimo de dos serologías, al comienzo y al final del embarazo, ya que 15% de las embarazadas reactivas lo son sólo al final de la gestación; la disponibilidad de la cordocentesis a partir de la decimaséptima semana del embarazo, con el fin de obtener muestras de sangre para diagnóstico prenatal; la aceptación de 9.600.000 U. de penicilina benzatínica para el tratamiento de la sífilis durante el embarazo; esta dosis evita los casos de niños Infectados que se han observado con el esquema de 7.200.000 U.

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Congenital Syphilis

Cited by 16 publications

References 0 publications

Diagnosis of Mercurial Teeth in a Possible Case of Congenital Syphilis and Tuberculosis in a 19th Century Child Skeleton

Diagnosis of Mercurial Teeth in a Possible Case of Congenital Syphilis and Tuberculosis in a 19th Century Child Skeleton

Syphilis: Review with Emphasis on Clinical, Epidemiologic, and Some Biologic Features

Sífilis congénita

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