Congestive heart failure from left ventricular diastolic dysfunction in systemic hypertension

Iriarte, Marian; Murga, Nekane; Sagastagoitia, D; Molinero, E; Morillas, Miren; Coronas, Alberto; Estella, Pedro; J, Etxebeste

doi:10.1016/0002-9149(93)90796-f

Cited by 76 publications

(18 citation statements)

References 17 publications

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“…Approximately 40% of all cases of congestive heart failure occur in patients with normal systolic function due to impaired diastolic LV filling, and systemic hypertension appears as the most frequent etiology (17,18). Cuocolo et al (19) investigated a population of 19 hypertensive patients, coincidently with the same mean LV mass of 141 g/m2 and the same PFR of 2.5 EDV/s as in our study.…”

Section: Discussionsupporting

confidence: 57%

Losartan Improves Diastolic Ventricular Filling of Hypertensive Patients with Diastolic Dysfunction.

Ayoub¹,

Vítola²,

Parro³

et al. 1999

Hypertens Res

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To evaluate the role of losartan on left ventricular (LV) function of hypertensive patients. Hypertensive patients (n =19) underwent evaluation of systolic and diastolic LV function, using radionuclide ventriculography (RVG), before and at 3 mo into the treatment with the angiotensin II antagonist losartan. All patients underwent a baseline 12 lead ECG and an echocardiogram (ECHO), which was also repeated at 3 mo into treatment. Results are expressed as mean ± SEM and statistics were performed using paired t-test. A p value <_ 0.05 was considered significant. Treatment with losartan for 3 mo had no effect on LV mass measured by echo (141 ± 5 vs. 139 ± 6 g/m2). The LV ejection fraction, measured by RVG, was unchanged by treatment when compared to the baseline study (58 ± 2 % vs. 57 ± 2% , respectivelly, p = 0.49). Considering all patients involved in the study (n =19), the LV "Peak Filling Rate" (PFR), a parameter of diastolic function measured by RVG, was also unchanged by treatment when compared to baseline (2.5 ± 0.2 EDV/s vs. 2.5 ± 0.3 EDV/s, respectively, p = 0.9). However the analysis of those patients with evidence of diastolic dysfunction (n =12) on the baseline RVG (PFR < 2.5 EVD/s), demonstrated significant improvement of LV filling after therapy with losartan (PFR =1.8 ± 0.1 EDV/s vs. 2.3 ± 0.2 EDV/s, respectively, p = 0.05). This change was associated with improvement of symptoms. Our results demonstrated that hypertensive patients with diastolic dysfunction on radionuclide ventriculography have significant improvement of ventricular filling at 3 mo into treatment with losartan. (Hypertens Res 1999; 22: 155-159)

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Section: Discussionsupporting

confidence: 57%

Losartan Improves Diastolic Ventricular Filling of Hypertensive Patients with Diastolic Dysfunction.

Ayoub¹,

Vítola²,

Parro³

et al. 1999

Hypertens Res

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show abstract

“…Approximately 20% to 40% of patients with HF have preserved left ventricular systolic function and (in the absence of valvular disease) are believed to have an impairment of ventricular relaxation as the primary mechanism leading to symptoms (27)(28)(29)(30)(31). Several recognized myocardial disorders are associated with diastolic dysfunction, including restrictive cardiomyopathy, obstructive and nonobstructive hypertrophic cardiomyopathy, and infiltrative cardiomyopathies.…”

Section: Diastolic Dysfunctionmentioning

confidence: 99%

ACC/AHA Guidelines for the Evaluation and Management of Chronic Heart Failure in the Adult: Executive Summary A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1995 Guidelines for the Evaluation and Management of Heart Failure)

Hunt¹,

Baker²,

Chin³

et al. 2001

Circulation

1,660

1,222

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“…Besides, the combined use of DRI and carvedilol will help in better blood pressure control since 88% patients with HFPSF have a history of chronic systolic hypertension [60,61]. A combination therapy with DRI and carvedilol might have a supra additive effect in regression of LV hypertrophy and fibrosis which is the cause of diastolic dysfunction in HPSF.…”

Section: Resultsmentioning

confidence: 99%

Combined use of direct renin inhibitor and carvedilol in heart failure with preserved systolic function

Badheka¹,

Tuliani²,

Rathod³

et al. 2012

Medical Hypotheses

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Congestive heart failure from left ventricular diastolic dysfunction in systemic hypertension

Cited by 76 publications

References 17 publications

Losartan Improves Diastolic Ventricular Filling of Hypertensive Patients with Diastolic Dysfunction.

Losartan Improves Diastolic Ventricular Filling of Hypertensive Patients with Diastolic Dysfunction.

Combined use of direct renin inhibitor and carvedilol in heart failure with preserved systolic function

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