Congestive heart failure in two pet rabbits

Lord, Brigitte; Devine, Craig; Smith, Stuart F.

doi:10.1111/j.1748-5827.2010.01016.x

Cited by 12 publications

(2 citation statements)

References 8 publications

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“…Der Herzultraschall stellt inzwischen auch beim Kaninchen das Diagnostikum der Wahl dar, um intrakardiale Veränderungen zu erfassen und ihre Folgeerscheinungen zu bewerten (10,18,20,24,26). Unter Verwendung der erstellten Referenzwerte für M-Mode, 2D-Mode und Doppler-Echokardiographie ist eine detaillierte Beurteilung auch bei dieser Tierart möglich (10,18).…”

Section: Diskussionunclassified

Restriktiver Ventrikelseptumdefekt bei einem Zwergkaninchen

Hildebrandt

Leuser²,

Miltz³

et al. 2016

Tierarztl Prax Ausg K

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A 9-week-old intact female dwarf rabbit was presented for evaluation of a heart murmur. Physical examination revealed a grade IV/VI systolic heart murmur with the maximal intensity over the right heart base. Evidence for a left-sided cardiomegaly was present on lateral and dorsoventral radiographs. An electrocardiogram was recorded in right lateral recumbency, which revealed a sinus tachycardia with a heart rate of 360 beats/minute. Echocardiography showed normal dimensions for the atria and ventricles. Two-dimensional echocardiography confirmed the presence of a perimembranous ventricular septal defect (VSD) with a diameter of 0.8 mm. Identification of the VSD was possible from a right (long and short axes) and a left parasternal window. Peak flow velocity of the systolic left to right shunt was 5.2 m/s. Additionally, a relative pulmonic stenosis (peak flow in the pulmonary artery of 1.02 m/s, pulsed-wave Doppler) was present. According to these findings, the VSD was classified as restrictive. At this time point, medical treatment was unnecessary. The re-examination after 7 weeks revealed unchanged morphological and haemodynamic findings. The VSD in this dwarf rabbit displayed both in the physical and echocardiographic examinations typical features as seen in dogs and cats as well as in one New Zealand white rabbit.

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Section: Diskussionunclassified

Restriktiver Ventrikelseptumdefekt bei einem Zwergkaninchen

Hildebrandt

Leuser²,

Miltz³

et al. 2016

Tierarztl Prax Ausg K

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“…C ardiovascular disease in rabbits has historically been described as an uncommon disease with previous literature limited to occasional case reports and anecdotal information [1][2][3][4][5][6][7][8][9] Rabbits have been used extensively as animal models for atherosclerosis, endocarditis, and drug-induced ardiomyopathies. [10][11][12] A recent retrospective study 3 on cardiovascular disease at a veterinary teaching hospital described an overall prevalence of 2.6%.…”

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confidence: 99%

Pharmacokinetics of pimobendan following oral administration to New Zealand White rabbits (Oryctolagus cuniculus)

Ozawa

Guzmán

Hawkins

et al. 2022

ajvr

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OBJECTIVE To determine the pharmacokinetics and potential adverse effects of pimobendan after oral administration in New Zealand White rabbits (Ocytolagus cuniculi). ANIMALS 10 adult sexually intact (5 males and 5 females) rabbits. PROCEDURES 2 pilot studies were performed with a pimobendan suspension or oral tablets. Eight rabbits received 7.5 mg of pimobendan (mean 2.08 mg/kg) suspended in a critical care feeding formula. Plasma concentrations of pimobendan and O-demethylpimobendan (ODMP) were measured, and pharmacokinetic parameters were calculated for pimobendan by noncompartmental analysis. Body weight, food and water consumption, mentation, urine, and fecal output were monitored. RESULTS Mean ± SD maximum concentration following pimobendan administration was 15.7 ± 7.54 ng/mL and was detected at 2.79 ± 1.25 hours. The half-life was 3.54 ± 1.32 hours. Plasma concentrations of pimobendan were detectable for up to 24 hours. The active metabolite, ODMP, was detected in rabbits for 24 to 36 hours. An adverse event occurred following administration of pimobendan in tablet form in 1 pilot study, resulting in death secondary to aspiration. No other adverse events occurred. CLINICAL RELEVANCE Plasma concentrations of pimobendan were lower than previously reported for dogs and cats, despite administration of higher doses, and had longer time to maximum concentration and half-life. Based on this study, 2 mg/kg of pimobendan in a critical care feeding formulation should maintain above a target plasma concentration for 12 to 24 hours. However, further studies evaluating multiple-dose administration as well as pharmacodynamic studies and clinical trials in rabbits with congestive heart failure are needed to determine accurate dose and frequency recommendations.

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Rabbits

2017

Pathology of Small Mammal Pets

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Congestive heart failure in two pet rabbits

Cited by 12 publications

References 8 publications

Restriktiver Ventrikelseptumdefekt bei einem Zwergkaninchen

Restriktiver Ventrikelseptumdefekt bei einem Zwergkaninchen

Pharmacokinetics of pimobendan following oral administration to New Zealand White rabbits (Oryctolagus cuniculus)

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