A numerical investigation of the effect of the Reynolds number on the thermal and hydrodynamic parameters of mixed convection heat transfer of the water-Al 2 O 3 nanofluid turbulent flow in an inclined circular channel is the subject of this article. The upper wall of the channel was under non-uniform heat flux and its lower part was isolated. The two-phase mixture model, the finite volume method, and the secondorder upstream difference scheme were used to solve the governing equations. After reviewing the results, it was found that by increasing Reynolds number, the convective heat transfer coefficient and shear stress increase, but the surface friction coefficient decreases. In the case of Nusselt number and the surface friction coefficient, some equations were extracted.