Conjunctival leiomyosarcoma: A case report and review of literature

Abstract

Leiomyosarcoma is a malignant mesenchymal tumor that is very uncommon in the conjunctiva. Nevertheless, we describe here the clinical manifestations, management, and prognosis of a rare case of leiomyosarcoma in this location. An 81-year-old male presented at a tertiary hospital with a rapidly growing mass. After performing biopsy, histopathological examination revealed the existence of a conjunctival leiomyosarcoma. On this diagnosis, a thorough metastatic screening was performed showing no enlarged lymph nodes or metastatic deposits anywhere in the body. To treat the condition, we performed an evisceration with clear margins and subsequent radiotherapy.

Conjunctival Leiomyosarcoma, a Rare Neoplasm Always Originating at the Limbus? Report of a New Case and Review of 11 Published Cases

“…A literature search was conducted on PubMed and Web of Science, using the terms leiomyosarcoma, conjunctiva, eye, and orbit. Ten papers describing 11 cases of leiomyosarcoma of the conjunctiva were included [17][18][19][20][21][22][23][24][25][26]. Including our case, all 12 cases are summarized in Table 1.…”

“…In 10 of the 12 cases, the authors explicitly describe a subconjunctival lesion located at the limbus, or a picture shows a small lesion at the limbus [22] or both [23,24]. In the other two larger exophytic lesions also involving fornix or anterior orbit, the initial site of the lesion was reported by the patient to be a small nodule [21,25]. In order to be visible for a patient, the lesion will be located anteriorly.…”

“…Metastatic leiomyosarcoma to the orbit and choroid have also been reported [11][12][13][14][15][16]. Until present, 11 cases of leiomyosarcoma of the conjunctiva have been reported [17][18][19][20][21][22][23][24][25][26]. Two of them had anterior orbital invasion [21,24].…”

Reply to Conjunctival leiomyosarcoma: A case report and review of literature

“…I thank the author for the interest shown in our published article and appreciate the new information reported. [ 1 ]…”

Conjunctival leiomyosarcoma: A case report and review of literature

“…I read with interest the case report on the conjunctival leiomyosarcoma reported by Montes et al . [ 1 ] Leiomyosarcoma is one of the most common and serious smooth muscle tumors (SMTs) in the body. Patients infected with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) are susceptible to various types of tumors, including SMTs.…”