2023
DOI: 10.1111/srt.13395
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Connections between cohesion and properties that related to safety and effectiveness of the hyaluronic acid dermal fillers: A comparative study of the cohesive and non‐cohesive gels

Xiaotong Wang,
Hongwei Xi,
Changzheng Wei

Abstract: BackgroundAlthough the importance of the cohesion of a hyaluronic acid (HA) filler has been recognized, the relationship between the cohesion and the other performance that related to safety and effectiveness, as well as the underlying mechanism is barely studied. Much efforts need to be made on this subject to provide guidance for clinical practice.Materials and methodsTwo types of the HA fillers (cohesive and particulate gels) were selected for the comparison of the cohesion and the other key physicochemical… Show more

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“…Although manufactured with different processes, the aforementioned gels share a more "monophasic" aspect than the "particulate" gels. Several parameters, like the size of the particles and the cohesivity of the gels, partly explain these differences [29]. In addition, high-molecular-weight polymers are known to stress-relax more slowly than their low-molecular-weight counterparts [16].…”
Section: Discussionmentioning
confidence: 99%
“…Although manufactured with different processes, the aforementioned gels share a more "monophasic" aspect than the "particulate" gels. Several parameters, like the size of the particles and the cohesivity of the gels, partly explain these differences [29]. In addition, high-molecular-weight polymers are known to stress-relax more slowly than their low-molecular-weight counterparts [16].…”
Section: Discussionmentioning
confidence: 99%