Connective tissue responses to calcium hydroxide‐based root canal medicaments

Filho, Paulo Nelson; Silva, L. A. Bezerra; Leonardo, Mário Roberto; Utrilla, L S; Figueiredo, Florêncio

doi:10.1046/j.1365-2591.1999.00225.x

Cited by 52 publications

(32 citation statements)

References 14 publications

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“…Previous studies have reported that calcium hydroxide induces a lesser degree of inflammatory infiltrate in the initial hours, progressing to a moderate degree after longer periods, and inducing subsequent tissue repair. 20 The necrosis seen in pulp tissue following contact with calcium hydroxide is the result of its alkalinity. This alkalinity actually has a beneficial effect on the injured tissue, insofar as it causes mild irritation and stimulates the conjunctive tissue to defend and repair itself, initiating an inflammatory reaction to control and eliminate the irritating agent.…”

mentioning

confidence: 99%

Inflammatory effect of green propolis on dental pulp in rats

Esmeraldo

Carvalho

et al. 2013

Braz. oral res.

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mentioning

confidence: 99%

Inflammatory effect of green propolis on dental pulp in rats

Esmeraldo

Carvalho

et al. 2013

Braz. oral res.

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“…In addition, it presents pH around 12.4 (9), high antibacterial activity (8), and biocompatibility (9,10).…”

mentioning

confidence: 99%

Effects of the Association between a Calcium Hydroxide Paste and 0.4% Chlorhexidine on the Development of the Osteogenic Phenotype In Vitro

Leonardo

Silva

Castro

et al. 2008

Journal of Endodontics

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“…This may be due to responses to initial irritation in short periods when in touch with the tested material, or due to the surgical procedure [23]. Different results were observed by Nelson Filho et al [24], who reported that calcium hydroxide induces less inflammatory infiltrate in the initial hours, progressing to a moderate degree after longer periods, and inducing subsequent tissue repair.…”

Section: Discussionmentioning

confidence: 99%

Biocompatibility of propolis in subcutaneous tissue of rats: a possible biomaterial for cavity cleansing

Almeida

Ferreira

Venâncio

et al. 2017

Rev. Odonto Ciênc. (Online)

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OBJECTIVE: The aim of this study was to histopathologically analyze, in subcutaneous connective tissue in rats, a propolis solution for cavity cleansing and its toxicity through hemolytic and Artemia franciscana tests. METHODS: Fifteen male rats were selected and randomly distributed in three experimental periods (07, 30 and 45 days), in which each animal received the four treatment groups in rounds: Group IPropolis I; Group II -Propolis II; Group III -Calcium Hydroxide Water and Group IV -2% Chlorexidine; the sides of the tube were the control group. The data were analyzed using descriptive statistics. The results showed, in terms of biocompatibility, that all materials presented a significant reduction of the inflammatory infiltrate and an increase of the thickness in the collagen fibers. It may be suggested, in decreasing order of biocompatibility, the use of following materials: calcium hydroxide-water, 2% chlorexidine, propolis I and propolis II. RESULTS: In the cytotoxicity test using A. franciscana, the propolis extract showed high toxicity when tested at concentrations and in the hemolytic activity test the propolis I extract showed greater activity than propolis II. CONCLUSION: The present study suggests the use of propolis as a cavity cleansing solution for shallow and medium cavities similar to 2% chlorexidine.Key words: Materials testing; Propolis; Dental cavity lining; Detergents Biocompatibilidade da própolis no tecido subcutâneo de ratos: um possível biomaterial de limpeza de cavidade RESUMO OBJETIVO: O objetivo deste estudo foi analisar histopatologicamente, em tecido conjuntivo subcutâneo de ratos, uma solução de própolis para a limpeza de cavidades e sua toxicidade através dos testes de hemólise e Artemia franciscana. METODOLOGIA: Foram utilizados 15 ratos machos, selecionados e distribuídos aleatoriamente em três grupos (n=5) em períodos experimentais (7, 30 e 45 dias), em que cada animal recebeu os quatro grupos de tratamento em forma de rodízio: Grupo I -Própolis I; Grupo II -Própolis II; Grupo III -Água de Hidróxido de Cálcio e Grupo IV -Clorexidina a 2%; as laterais do tubo foram o grupo controle. Os dados foram analisados pela estatística descritiva. RESULTADOS: Todos os materiais apresentaram uma redução significativa do infiltrado inflamatório e aumento da espessura das fibras colágenas. No teste de citotoxicidade de Artemia franciscana, o extrato de própolis apresentou alta toxicidade e no teste de atividade hemolítica o extrato de Própolis I mostrou-se mais ativo que o da Própolis II. CONCLUSÃO: O presente estudo mostrou a biocompatibilidade da própolis, sugerindo seu uso como solução de limpeza em cavidade cavidades rasas e médias semelhante à clorexidina a 2%.

show abstract

Connective tissue responses to calcium hydroxide‐based root canal medicaments

Abstract: All calcium hydroxide formulations caused an inflammatory response. The severity and longevity of the responses varied between pastes as a result of the various antiseptic agents. Although irritating, repair was apparent with all formulations.

Cited by 52 publications

References 14 publications

Inflammatory effect of green propolis on dental pulp in rats

Inflammatory effect of green propolis on dental pulp in rats

Effects of the Association between a Calcium Hydroxide Paste and 0.4% Chlorhexidine on the Development of the Osteogenic Phenotype In Vitro

Biocompatibility of propolis in subcutaneous tissue of rats: a possible biomaterial for cavity cleansing

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