Connexin 43 contributes to the sensitization of colorectal cancer cells to photodynamic therapy through Akt inhibition

Wang, Yijia; Chen, Lankai; Lai, Sizhen; Liu, Yanfei; Yi, Ben; Zhu, Siwei; Hu, Xia; Zhang, Qinghuai; Zhang, Chunze

doi:10.1016/j.pdpdt.2022.103040

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…Moreover, kanglaite increases Cx43 expression and down-regulates NF-κΒ in promoting Taxol sensitivity of tumor cells [ 86 ]. Furthermore, Cx43 suppresses Akt signaling in increasing efficacy of photodynamic therapy in impairing CRC progression [ 87 ]. High concentration of OXA decreases Cx43 expression, while promoting Cx43 expression is of importance in promoting OXA sensitivity of CRC cells via gap junctional c0ommunication function [ 88 ].…”

Section: Onco-suppressor Pathways and Oxaliplatin Chemotherapymentioning

confidence: 99%

Biological landscape and nanostructural view in development and reversal of oxaliplatin resistance in colorectal cancer

Hashemi,

Esbati,

Rashidi

et al. 2024

Translational Oncology

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Section: Onco-suppressor Pathways and Oxaliplatin Chemotherapymentioning

confidence: 99%

Biological landscape and nanostructural view in development and reversal of oxaliplatin resistance in colorectal cancer

Hashemi,

Esbati,

Rashidi

et al. 2024

Translational Oncology

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“…PDT can be combined with other treatment modalities, such as chemotherapy (e.g., 5-FU [161] , doxorubicin [74] , oxaliplatin [100] ), immunotherapy (e.g., anti-PD-L1 antibody [162][163][164] , CTLA-4 inhibitors [101] ), targeted therapy (e.g., bevacizumab [165] , Cetuximab [166] ), or small molecule inhibitors (e.g., inhibitors of COX-1 and COX-2 [167] , proteasome inhibitors [168] , AKT inhibitors [169] , autophagy inhibitors [113,170] ), to enhance the overall therapeutic effect. This multimodal approach holds the potential to improve treatment outcomes, especially in cases where diseases have advanced or exhibit resistance to conventional therapies.…”

Section: Combination Therapymentioning

confidence: 99%

Photodynamic Therapy for Inflammatory and Cancerous Diseases of the Intestines: Molecular Mechanisms and Prospects for Application

Deng,

Wang,

Zhang

et al. 2023

Int. J. Biol. Sci.

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Photodynamic therapy (PDT) is a minimally invasive treatment that effectively targets cancer and inflammatory diseases. It has gained recognition for its efficacy, low toxicity, and potential for repeated use. Colorectal cancer (CRC) and inflammatory bowel diseases (IBD), including Crohn's disease (CD), and ulcerative colitis (UC), impose a significant burden on global intestinal health, with increasing incidence and prevalence rates. PDT shows promise as an emerging approach for gastrointestinal disease treatment, particularly IBD and CRC. Extensive preclinical research has demonstrated the safety and effectiveness of PDT for IBD and CRC, while clinical studies are currently underway. This review provides an overview of the underlying mechanisms responsible for the anti-inflammatory and anti-tumor effects of PDT, offering insights into the clinical application of PDT in IBD and CRC treatment. It is expected that this review will serve as a valuable reference for future research on PDT for CRC and IBD, contributing to advancements in the treatment of inflammatory and cancerous diseases of the intestines.

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Connexin-43 in Cancer: Above and Beyond Gap Junctions!

Paunikar,

Tamagnone

2024

Cancers

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Connexin-43 (Cx43) is the most characterized gap junction protein, primarily involved in the Gap Junctional Intercellular Communication (GJIC) between adjacent cells to facilitate molecule exchange and the formation of a signaling network. It is increasingly evident that the importance of Cx43 is not only limited to its GJIC function, but rather includes its role in connecting the intracellular and extracellular environment by forming membrane hemichannels, as well as its intracellular signaling function mediated by its C-terminal tail (Cx43-CT). Notably, Cx43 has been implicated in a variety of cancers, with earlier notions suggesting a tumor-suppressor function, whereas new studies shed light on its pro-tumorigenic role. Moreover, apart from GJIC-based activities, the relevance of the non-canonical functions of Cx43 in tumor progression is being actively studied. This review provides an analysis of the current research on the pro-tumorigenic roles of Cx43, with a focus on Cx43-CT interactions and the function of hemichannels in cancer progression. A better understanding of the multifaceted functions of Cx43 in cancer biology could foster its recognition as a pivotal target for the development of innovative therapeutic strategies.

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Connexin 43 contributes to the sensitization of colorectal cancer cells to photodynamic therapy through Akt inhibition

Cited by 3 publications

References 19 publications

Biological landscape and nanostructural view in development and reversal of oxaliplatin resistance in colorectal cancer

Biological landscape and nanostructural view in development and reversal of oxaliplatin resistance in colorectal cancer

Photodynamic Therapy for Inflammatory and Cancerous Diseases of the Intestines: Molecular Mechanisms and Prospects for Application

Connexin-43 in Cancer: Above and Beyond Gap Junctions!

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