Connexin gap junction channels and chronic rhinosinusitis

Kim, Woojin; Chang, George J.; Hu, Rebecca; Phillips, Anthony R.J.; Douglas, Richard

doi:10.1002/alr.21717

Cited by 9 publications

(8 citation statements)

References 42 publications

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“…Gap junctions are also components of the innate immunity defence system by mediating the cell-to-cell spread of pro-inflammatory and pro-apoptotic signals according to the pathogen recognition receptors (PRRs) activated [ 18 , 19 ]. Hence, connexins and Panx1 are deregulated in terms of activity and/or expression in several pathologies, including chronic rhinosinusitis [ 20 ] and cystic fibrosis [ 21 , 22 ].…”

Section: Connexins In Normal and Repairing Airway Epitheliummentioning

confidence: 99%

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Connexin Communication Compartments and Wound Repair in Epithelial Tissue

Chanson

Watanabe

O'Shaughnessy

et al. 2018

IJMS

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Epithelial tissues line the lumen of tracts and ducts connecting to the external environment. They are critical in forming an interface between the internal and external environment and, following assault from environmental factors and pathogens, they must rapidly repair to maintain cellular homeostasis. These tissue networks, that range from a single cell layer, such as in airway epithelium, to highly stratified and differentiated epithelial surfaces, such as the epidermis, are held together by a junctional nexus of proteins including adherens, tight and gap junctions, often forming unique and localised communication compartments activated for localised tissue repair. This review focuses on the dynamic changes that occur in connexins, the constituent proteins of the intercellular gap junction channel, during wound-healing processes and in localised inflammation, with an emphasis on the lung and skin. Current developments in targeting connexins as corrective therapies to improve wound closure and resolve localised inflammation are also discussed. Finally, we consider the emergence of the zebrafish as a concerted whole-animal model to study, visualise and track the events of wound repair and regeneration in real-time living model systems.

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Section: Connexins In Normal and Repairing Airway Epitheliummentioning

confidence: 99%

“…Re-establishment of the integrity of the airway epithelium is a prerequisite to restoration of the tissue homeostasis and host-defence mechanisms [ 20 ]. The tracheobronchial airway epithelium is composed of BCs, GCs and CCs.…”

Section: Connexins In Normal and Repairing Airway Epitheliummentioning

confidence: 99%

Connexin Communication Compartments and Wound Repair in Epithelial Tissue

Chanson

Watanabe

O'Shaughnessy

et al. 2018

IJMS

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“…Together, these junction proteins function to limit intercellular passage of fluid and protect the underlying tissue from exposure to noxious and allergenic stimuli (London and Ramanathan, 2017). Epithelial cell communication is mediated via Gap junction channels, which are formed by connexin proteins enabling cell communication (Kim et al, 2016). Expression of connexins have been demonstrated to be increased in CRS compared to controls (Kim et al, 2016).…”

Section: Upper Airway Epithelial Functions During Ar and Crsmentioning

confidence: 99%

“…Epithelial cell communication is mediated via Gap junction channels, which are formed by connexin proteins enabling cell communication (Kim et al, 2016). Expression of connexins have been demonstrated to be increased in CRS compared to controls (Kim et al, 2016). Hence, epithelial barrier dysfunction may contribute to AR and CRS through allowing increased passage of antigens and exposure of underlying tissue to these stimuli (Toppila-Salmi et al, 2015;London and Ramanathan, 2017).…”

Section: Upper Airway Epithelial Functions During Ar and Crsmentioning

confidence: 99%

Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases

Laulajainen‐Hongisto

Toppila‐Salmi

Luukkainen

et al. 2020

Front. Cell Dev. Biol.

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Allergic rhinitis, chronic rhinosinusitis, and asthma are highly prevalent, multifactorial chronic airway diseases. Several environmental and genetic factors affect airway epithelial dynamics leading to activation of inflammatory mechanisms in the airways. This review links environmental factors to host epithelial immunity in airway diseases. Understanding altered homeostasis of the airway epithelium might provide important targets for diagnostics and therapy of chronic airway diseases.

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“…A recent report revealed that 16 connexin genes are expressed in the human sinus mucosa [ 3 ]. One report found that connexin-43 is significantly upregulated in CRS patients compared to healthy controls at both the mRNA and protein levels, whereas other reports searching for a potential cause of dysfunction in the sinonasal epithelium failed to find a significant difference in the expressions of connexin-26, -30, -32, or -43 [ 3 – 5 ]. Although the relationship between CRS and connexin expression is still controversial, those reports have consistently shown that connexin-43 is expressed in human nasal epithelial cells.…”

mentioning

confidence: 99%

Synchronized roles of pannexin and connexin in nasal mucosal epithelia

Ohbuchi

Suzuki

2018

Eur Arch Otorhinolaryngol

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BackgroundNasal mucosal epithelial cells express connexins, the prototypical gap junction proteins, and pannexins, a new family of channel proteins homologous to the invertebrate gap junction proteins. The physiological and pathophysiological roles of these transmembrane proteins in nasal mucosa are largely still unknown.PurposePannexins participate in ATP release into the extracellular space in various tissues, and ATP plays important roles in mucociliary clearance, especially by regulating ciliary beat activity. Therefore, we focused on the functional relationship between connexins, pannexin-1, ATP release, and mucociliary clearance in nasal epithelia.Results and ConclusionsConnexins participate in the generation of intercellular calcium waves, in which calcium-mediated signaling responses spread to contiguous cells through the gap junction formed by connexins to transmit calcium signaling throughout the airway epithelium. Pannexins in the nasal mucosa may contribute to not only ciliary beat modulation via ATP release, but also regulation of mucus blanket components via H2O efflux. The synchronized roles of pannexin and connexin may provide a new insight into effective mucociliary clearance systems in nasal mucosa.

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Connexin gap junction channels and chronic rhinosinusitis

Abstract: The majority of the connexin family is expressed in normal sinus mucosa. Expression of 3 selected connexins was found elevated in CRS mucosa. Connexin gap junction modulation may offer a novel therapeutic target for CRS.

Cited by 9 publications

References 42 publications

Connexin Communication Compartments and Wound Repair in Epithelial Tissue

Connexin Communication Compartments and Wound Repair in Epithelial Tissue

Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases

Synchronized roles of pannexin and connexin in nasal mucosal epithelia

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