Consensus and controversy in the management of paediatric and adult patients with ovarian immature teratoma: the Malignant Germ Cell International Consortium perspective

Pashankar, Farzana; Murray, Matthew J.; Gell, Joanna; MacDonald, Nicola; Shamash, Jonathan; Billmire, Deborah F.; Klosterkemper, Lindsay; Olson, Thomas; Hirsch, Michelle S.; Lockley, Michelle; Stoneham, Sara; Frazier, A. Lindsay

doi:10.1016/j.eclinm.2024.102453

Cited by 4 publications

(2 citation statements)

References 81 publications

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“…According to some previous reports, complete surgical resection of the gross tumor followed by observation is sufficient in pediatric patients, irrespective of both grading and staging [ 14 , 28 ]. A recent review on the management of pediatric and adult patients with ovarian ITs recommended strict follow-up alone after surgical resection for these children at the initial presentation and even if tumor relapse does occur [ 29 ]. Pashankar and colleagues documented in their study that tumor grading is the most significant factor for relapse.…”

Section: Discussionmentioning

confidence: 99%

Management strategy for children with ovarian immature teratoma: results from a tertiary pediatric oncology center

Ahmed,

Khalil,

Elshafiey

et al. 2024

World J Surg Onc

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Objectives We present an Egyptian study on pediatric ovarian immature teratomas (ITs), aiming to clarify our treatment strategy selection. Methods A retrospective review of all children with pure ovarian ITs who were treated at our institution between 2008 and 2023. The analysis included clinical characteristics, tumor staging according to Children’s Oncology Group (COG), grading based on the Norris system, management, and outcomes. Results Thirty-two patients were included, with a median age of 9 years. All patients underwent primary surgery. Unilateral salpingo-oophorectomy was performed in 31 patients. Surgical staging was completed in all patients. Based on COG staging, there were 28 patients (87.5%) stage I, 1 (3%) stage II, and 3 (9.5%) stage III. According to Norris classification, 16 patients (50%) were classified as grade I, 9 (28%) grade II, and 7 (22%) grade III. All patients in stage I were treated using surgery-alone approach, whereas the remaining four (12.5%) received adjuvant chemotherapy. Five patients in stage I had gliomatosis peritonei (GP), and none of them underwent extensive surgery. At a median follow-up of 86 months, two patients had events. The first patient (stage III/grade I) developed IT relapse on the operative bed, and the second (stage I/grade I) had a metachronous IT on the contralateral ovary. Both patients were successfully managed with surgery followed by second-line chemotherapy. Five-year overall survival and event-free survival for all patients were 100% and 93.4%, respectively. Conclusions Surgery-alone strategy with close follow-up achieves excellent outcomes for localized ovarian ITs in children, irrespective of the Norris grading or the presence of GP. However, adjuvant chemotherapy is questionable for patients with incompletely resected or locally advanced tumors, and its role requires further evaluation through prospective multicentric studies with a larger sample size.

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Section: Discussionmentioning

confidence: 99%

Management strategy for children with ovarian immature teratoma: results from a tertiary pediatric oncology center

Ahmed,

Khalil,

Elshafiey

et al. 2024

World J Surg Onc

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“…( 21 )Pashankar et al. ( 22 ). In scenarios where surgery is unfeasible or complete resection cannot be accomplished, alternative treatments such as Pazopanib have been reported in the literature as therapeutic options for GTS Schultz et al.…”

Section: Discussionmentioning

confidence: 99%

Growing teratoma syndrome of the ovary: a case report and literature review

Tao,

Shi,

et al. 2024

Front. Oncol.

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Growing teratoma syndrome (GTS) is a rare condition that arises secondary to malignant germ cell tumors. It is characterized by an enlarging abdominal mass during or after chemotherapy, normal tumor markers, and histopathological indications of mature teratoma components. Awareness of GTS is limited, and it is often mistaken for disease progression or recurrence. This misdiagnosis can lead to delayed treatment and increased risk of complications. Therefore, early identification of GTS is crucial to avoid unnecessary systemic treatments and reduce financial burden. GTS is unresponsive to chemotherapy or radiotherapy and complete surgical resection is the sole therapeutic strategy. In this report, we present a case of GTS in a 20-year-old female following treatment for immature teratoma, alongside a review of the relevant literature aimed at enriching our insight into the clinical manifestations of GTS.

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Laparoscopic-Assisted Fertility-Sparing Surgery for Growing Teratoma Syndrome of the Ovary: Experience From a Tertiary Center

Wang,

Jia,

Wang

et al. 2024

Journal of Minimally Invasive Gynecology

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Consensus and controversy in the management of paediatric and adult patients with ovarian immature teratoma: the Malignant Germ Cell International Consortium perspective

Cited by 4 publications

References 81 publications

Management strategy for children with ovarian immature teratoma: results from a tertiary pediatric oncology center

Management strategy for children with ovarian immature teratoma: results from a tertiary pediatric oncology center

Growing teratoma syndrome of the ovary: a case report and literature review

Laparoscopic-Assisted Fertility-Sparing Surgery for Growing Teratoma Syndrome of the Ovary: Experience From a Tertiary Center

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