Consensus Document of the Spanish Society of Cardiology and the Spanish Society of Internal Medicine on the diagnosis and treatment of iron deficiency in heart failure

Manito, Nicolás; Cerqueiro, J.M.; Comín‐Colet, Josep; García‐Pinilla, José Manuel; González-Franco, Álvaro; Amorós, Jordi Grau; Peraira, J.R; Manzano, Luís

doi:10.1016/j.rceng.2016.10.003

Cited by 13 publications

(9 citation statements)

References 65 publications

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“…86 yet guidelines often lack agreement on test cut-off values for these parameters. 4 Serum ferritin levels are TABLE 1 Iron deficiency anemia has more guideline coverage than iron deficiency: summary of iron deficiency diagnostic measures, independent of anemia [68][69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85] Recommended iron deficiency threshold values independent of anemia although a CRP level of 5 mg L 21 is the most common threshold, 64 this is not recognized in most guidelines 68…”

Section: Diagnosis Of Iron Deficiency In Chronic Inflammatory Condimentioning

confidence: 99%

Iron deficiency across chronic inflammatory conditions: International expert opinion on definition, diagnosis, and management

et al. 2017

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Iron deficiency, even in the absence of anemia, can be debilitating, and exacerbate any underlying chronic disease, leading to increased morbidity and mortality. Iron deficiency is frequently concomitant with chronic inflammatory disease; however, iron deficiency treatment is often overlooked, partially due to the heterogeneity among clinical practice guidelines. In the absence of consistent guidance across chronic heart failure, chronic kidney disease and inflammatory bowel disease, we provide practical recommendations for iron deficiency to treating physicians: definition, diagnosis, and disease‐specific diagnostic algorithms. These recommendations should facilitate appropriate diagnosis and treatment of iron deficiency to improve quality of life and clinical outcomes.

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Section: Diagnosis Of Iron Deficiency In Chronic Inflammatory Condimentioning

confidence: 99%

Iron deficiency across chronic inflammatory conditions: International expert opinion on definition, diagnosis, and management

et al. 2017

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“…This burden of disease is strongly influenced by the co-morbidities associated with HF, of which iron deficiency (ID) is one of the most common, occurring in approximately 50% of HF patients 7,8 . HF patients with ID (serum ferritin <100 lg/L, or ferritin between 100 and 299 lg/L and transferrin saturation <20%) 9,10 have been found to have lower functional capacity, poorer prognosis, impaired quality of life (QoL), and higher risk of hospitalization and mortality, independent of the presence of anemia 7,[11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

“…According to 2016 guidelines from the European Society of Cardiology (ESC) on the diagnosis and treatment of HF, and a consensus document from the Spanish Society of Cardiology and the Spanish Society of Internal Medicine, ID is a therapeutic target in patients with HF. ESC guidelines recommend the intravenous ferric carboxymaltose (FCM) as the only treatment for symptomatic patients with reduced left ventricular ejection fraction (LVEF) ( 45%) and ID 9,10,15 .…”

Section: Introductionmentioning

confidence: 99%

Budget impact of ferric carboxymaltose treatment in patients with chronic heart failure and iron deficiency in Spain

Delgado

Oliva

González-Franco

et al. 2020

Journal of Medical Economics

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Objective: The treatment of iron deficiency (ID) with ferric carboxymaltose (FCM) improves the functional class and quality of life of chronic heart failure (CHF) patients with reduced left ventricular ejection fraction (LVEF), and reduces the rate of hospitalization due to worsening CHF. This study aims to evaluate the budget impact for the Spanish National Health System (SNHS) of treating ID in reduced LVEF CHF with FCM compared to non-iron treatment. Methods: We simulated a hypothetical cohort of 1000 CHF patients with ID and reduced LVEF based on the Spanish population characteristics. A decision-analytic model was also built using the data from the largest FCM clinical trial (CONFIRM-HF) that lasted for a year. We considered the use of healthcare resources from a national prospective study. A deterministic sensitivity analysis was carried out varying the corresponding baseline data by ±25%. Results: The cost of treating the simulated population with FCM was e2,570,914, while that of the non-iron treatment was e3,105,711, which corresponds to a cost saving of e534,797 per 1,000 patients in one year. Cost savings were mainly due to a decrease in the number of hospitalizations. All sensitivity analysis showed cost savings for the SNHS. Conclusions: FCM results in an annual cost saving of e534.80 per patient, and would thus be expected to reduce the economic burden of CHF in Spain.

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“…Correction of this iron deficiency with intravenous iron has been shown to improve exercise tolerance in these patients [6]. Fixing the iron deficiency also reduced hospitalizations from heart failure decompensation [7].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of iron deficiency in a total joint surgery population

Waters

Johnson²,

Yazer

2018

Hematology

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Consensus Document of the Spanish Society of Cardiology and the Spanish Society of Internal Medicine on the diagnosis and treatment of iron deficiency in heart failure

Cited by 13 publications

References 65 publications

Iron deficiency across chronic inflammatory conditions: International expert opinion on definition, diagnosis, and management

Iron deficiency across chronic inflammatory conditions: International expert opinion on definition, diagnosis, and management

Budget impact of ferric carboxymaltose treatment in patients with chronic heart failure and iron deficiency in Spain

Prevalence of iron deficiency in a total joint surgery population

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