2019
DOI: 10.1016/j.mito.2019.06.001
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Consequences of inner mitochondrial membrane protein misfolding

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Cited by 23 publications
(16 citation statements)
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“…Such stress responses are implicated in several pathological conditions like aging, muscle degeneration, and neurodegeneration (Lin and Beal, 2006, Tatsuta and Langer, 2008, Zhu et al, 2021). In addition, the accumulation of these hydrophobic proteins in the cytosol further dampens the import of other essential cytosolic and mitochondrial proteins (Coyne and Chen, 2019). Also, overloading of the carrier proteins in humans induces cytosolic aggresomes and activates apoptotic pathways (Liu et al, 2019).…”
Section: Discussionmentioning
confidence: 99%
“…Such stress responses are implicated in several pathological conditions like aging, muscle degeneration, and neurodegeneration (Lin and Beal, 2006, Tatsuta and Langer, 2008, Zhu et al, 2021). In addition, the accumulation of these hydrophobic proteins in the cytosol further dampens the import of other essential cytosolic and mitochondrial proteins (Coyne and Chen, 2019). Also, overloading of the carrier proteins in humans induces cytosolic aggresomes and activates apoptotic pathways (Liu et al, 2019).…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies reported that MIC60 was altered and misfolded under several different pathological conditions [ 29 , 30 ]. To maintain homeostasis in cells, misfolded proteins may be refolded to normal structure with the help of molecular chaperones, or degraded through a ubiquitin-proteasome system or lysosome [ 31 ]. TRAP1 was reported to regulate mitochondrial proteins quality control and ubiquitination [ 32 ].…”
Section: Introductionmentioning
confidence: 99%
“…Accumulation of mtDNA mutations may be a consequence of the loss of mtDNA replication precursors following membrane permeabilization [ 42 ]. More recently, it was proposed that misfolding and propensity to form large aggregates by Aac2 mutant could generate stress on the membrane, affecting mitochondrial biogenesis, particularly causing severe damage to the electron transport chain assembly and mtDNA integrity [ 45 , 251 , 252 ]. Nevertheless, the experiments performed so far are not yet conclusive, and none of these hypotheses seem to be totally clarifyied for now.…”
Section: Genes Studied In Yeastmentioning
confidence: 99%