Consequences of Long-Lasting Persistent Allergic Rhinitis in Adolescents

Abstract

While it is well known that asthma is characterized by airway remodelling, only few studies have investigated this issue in patients affected by allergic rhinitis (AR). The aim of the present study is to investigate functional and structural consequences of long-lasting persistent AR (PER) in a cohort of adolescents. Eighty patients, forty with short-lasting and forty with long-lasting PER were prospectively and consecutively evaluated both clinically and by performing skin prick test, nasal cytology, and rhinomanometry. Eosinophils were significantly higher in patients presenting with long-lasting PER rather than in those with short-lasting PER (P<O.OOOI). The degree of inflammation was significantly associated with impaired nasal airflow (r,=-0.81). This study provides evidence that adolescents with long-lasting PER may show a progressive worsening of nasal function depending on the inflammation.

The Expression of TSLP Receptor in Chronic Rhinosinusitis with and without Nasal Polyps

“…Increased levels of TSLP in nasal mucosa of patients affected by allergic rhinitis have been reported by Mou (17)(18) and, in a recent study, Liu et al showed high levels ofTSLP in nasal epithelial layer of patients with nasal polyps (19).…”

Association of childhood perennial allergic rhinitis with subclinical airflow limitation

“…Indeed, continuous exposure to mite allergen induces the persistence of inflammatory phenomena, which induce worsening of respiratory function [17]. In this regard, it has been reported recently that the duration of mite allergy induces a significant reduction of nasal airflow in adolescents [18]. Chronic nasal inflammation is also likely to result in hypertrophy of the nasal turbinates, thus inducing impaired passage to airflow.…”

Impact of IL-32 on Histamine Release by Human Derived Umbilical Cord Blood Mast Cells

“…IL-32 was cloned as a gene induced by IL-18, and the fact that IL-32related cytokines, TNFa. and IL-18 show a close correlation with inflammatory diseases implies that IL-32 has a pathologic role in inflammation (22)(23)(24)(25)(26).…”