2021
DOI: 10.1111/ede.12389
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Conservation biology meets evo‐devo: How understanding the emergence of variation can inform its management

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“…Hence, a plausible evo-devo view [ 77 ] of our results is that disrupting the conserved intragenic CpG structure of Trp53 –in this study, either by synonymously removing all 22 exonic CpG sites, or else by inserting 72 synonymous CpG sites–deranges the topology of site-specific MBP (e.g., MeCP2 or MBD2) interactions with Trp53 , leading to loss of pro-apoptotic gene function in the developing tooth bed [ 78 , 79 ], e.g., by splice-dependent [ 80 ] or chromatin-based trans -repression mechanisms [ 81 , 82 ]. Consistent with this, TP53 is downregulated in proliferative dental pathologies such as odontogenic keratocysts and ameloblastomas [ 83 ].…”
Section: Discussionmentioning
confidence: 99%
“…Hence, a plausible evo-devo view [ 77 ] of our results is that disrupting the conserved intragenic CpG structure of Trp53 –in this study, either by synonymously removing all 22 exonic CpG sites, or else by inserting 72 synonymous CpG sites–deranges the topology of site-specific MBP (e.g., MeCP2 or MBD2) interactions with Trp53 , leading to loss of pro-apoptotic gene function in the developing tooth bed [ 78 , 79 ], e.g., by splice-dependent [ 80 ] or chromatin-based trans -repression mechanisms [ 81 , 82 ]. Consistent with this, TP53 is downregulated in proliferative dental pathologies such as odontogenic keratocysts and ameloblastomas [ 83 ].…”
Section: Discussionmentioning
confidence: 99%