Objectives: Outcome sclerosing agent for managing the oral pyogenic granulomain terms of post-operative pain, post-operative healing and post-operative infection. Study Design: Cross-section study. Setting: Department of Oral & Maxillofacial Surgery, Institute of Dentistry, Liaquat University of Medical & Health Sciences Jamshoro / Hyderabad. Period: October 2018 to March 2019. Material & Methods: Patients with oral pyogenic granuloma and willing to contribute in study were included. Sclerosing agent (ethanolamine oleate) was taken in 3cc disposable syringe and injected in each lesion once a week and repeated according to need. Patients were fooled for 1 to 3 weeks. Outcome was assessed in terms of post-operative pain, post-operative healing and post-operative infection. Data was recorded in proforma. Results: Total seventy four patients were included; their mean age was 40.67+4.99 years. Males were in majority 59.5%. On 1st week 32 showed mild pain which was markedly decreased on 2nd and 3rd week almost among all patients. On 1st week healing was achieved by all cases. Infection was occurred in 4 patients and fever was noted in 12 cases. On 2nd week infection was occurred in 2 patients and fever was in 04 cases. On 3rd week infection was noted in only one cases and fever not found. Conclusion: It was concluded that sclerosing agent ethanolamine oleate is better treatment option than surgical removal with lower rate of pain, best achievement of post-operative healing and lower rate of post-operative infection for the oral pyogenic granuloma management.