Conservative approach to the treatment of Bowen's disease of the anus

Ramos, Paul; Salinas, Hugo C.; Tucker, L. George

doi:10.1007/bf02554979

Cited by 21 publications

(9 citation statements)

References 14 publications

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“…19 Ramos et al described two patients with anal Bowen's disease treated with 5 percent 5-FU. 20 5-FU prevents thymine syntheses by inhibition of thymidylate synthetase and suppresses the utilization of preformed uracil by blocking uracil monophosphate. 21,22 Because DNA and RNA are essential for cell growth, 5-FU may account for impaired cell growth resulting in cell death.…”

Section: Discussionmentioning

confidence: 99%

Topical 5-Fluorouracil in the Management of Extensive Anal Bowen's Disease: A Preferred Approach

Graham

Jetmore

Foote³

et al. 2005

Diseases of the Colon &Amp; Rectum

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Section: Discussionmentioning

confidence: 99%

Topical 5-Fluorouracil in the Management of Extensive Anal Bowen's Disease: A Preferred Approach

Graham

Jetmore

Foote³

et al. 2005

Diseases of the Colon &Amp; Rectum

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“…These methods include cryotherapy, argon laser therapy, photodynamic therapy, radiotherapy, 5-fluorouracil, infrared coagulation, imiquimod and close follow-up. 14,15,16,17,18,19 Especially, recent treatment guidelines report that radiotherapy is also highly effective and safe. 6 There is no standard protocol for follow-up of anal Bowen's disease.…”

Section: Discussionmentioning

confidence: 99%

Anal Bowen’s Disease: Retrospective Analysis of Five Cases

Akıncı¹,

Kutluk²,

Ertürk³

et al. 2018

TJCD

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Amaç: Anal Bowen hastalığı anüsün nadir görülen in-situ skuamöz hücreli kanseridir. Perianal bölgede kaşıntı, yanma, ağrı gibi semptomlar hastaların ilk başvuru sebepleridir. Hastalığın psöriazis, Paget hastalığı, egzema, seboreik dermatit, liken planus gibi birçok dermatolojik hastalıkla ayrımı yapılmalıdır. Etiyolojide arsenik, radyasyon maruziyeti, human papilloma virüs, immünosüpresyon gibi faktörler tanımlanmıştır. Bu yazımızda kliniğimizde teşhisi konularak tedavi edilen beş anal Bowen olgusunu retrospektif olarak inceledik. Yöntem: Kliniğimizde 2000-2017 yılları arasında anal Bowen hastalığı tanısı konulan ve tedavi edilen beş olguda yaş, cinsiyet, semptom, lezyon boyutu, cerrahi tedavi tekniği, eşlik eden hastalık ve predispozan faktörler retrospektif olarak incelendi. Bulgular: Olguların yaş ortalaması 64, üçü kadın ikisi erkek olup en sık görülen semptom anal kaşıntıydı. Olgulardan biri tedaviyi reddetmiş, ikisine eksizyon + primer sütür uygulanmıştır. Bir olguda eksizyon + Limberg flebi diğerinde ise V-Y ilerletme flebi uygulanmıştır. Sonuç: Anal Bowen hastalığı nadir görülen in-situ skuamöz hücreli karsinomdur. Tanısı lezyondan biyopsi ile konulur. Tedavisinde geniş cerrahi eksizyon kür sağlayıcı ve güvenilir bir yöntem olup rekonstruksiyon için primer tamir veya deri flepleri uygulanabilir. Anahtar Kelimeler: Anal Bowen hastalığı, cerrahi, tedavi ABSTRACT ÖZAim: Anal Bowen's disease is a rare in-situ squamous cell carcinoma of the anus. Symptoms such as pruritus, burning, and pain in the perianal region are the first complaints of patients at admission. The disease should be differentiated from many dermatological diseases such as psoriasis, Paget's disease, eczema, seborrheic dermatitis, and lichen planus. Factors such as human papilloma virus, arsenic, radiation exposure, and immunosuppression have been idefined in the etiology. In this study, we retrospectively reviewed five patients who were diagnosed with and treated for anal Bowen's disease in our clinic. Method: We retrospectively analyzed parameters such as age, gender, symptoms, lesion size, surgical treatment technique, comorbidity, and predisposing factors of five patients who were diagnosed with anal Bowen's disease and treated surgically in our clinic between 2000 and 2017.Results: The mean age of the cases was 64 years. Three were female and two were male. The most common symptom was anal itching. One of the patients refused treatment, while two underwent excision + primary suture. One patient underwent excision + Limberg flap, while excision + V-Y advancement flap were performed in the other case. Conclusion: Anal Bowen's disease is a rare in-situ squamous cell carcinoma that is diagnosed by lesion biopsy. Wide surgical excision is a safe and definitive treatment. Primary repair or skin flaps can be used for reconstruction.

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“…Die langsam wachsende Natur dieser Läsionen und die oftmals nur geringen Begleitsymptome führen häufig zur einer Diagnoseverzögerung [7]. Es bestehen zahlreiche Therapieoptionen bei perianalem Morbus Bowen, einschließlich Kryochirurgie [8], 5-Fluorouracil-Salbe [9], Argon-Laserbehandlung [10], photodynamischer Therapie [11] und alleiniger Beobachtung [12]. Allerdings wird die chirurgische Exzision als die Methode der Wahl angesehen [3,6,7] Kompasses (insgesamt 24 Biopsieproben).…”

Section: Patienten Und Methodikunclassified

Ergebnisse, Risiko weiterer Malignome und Notwendigkeit formaler Mapping-Verfahren bei Patienten mit perianalem Morbus Bowen*

Margenthaler¹,

Dietz²,

Mutch³

et al. 2005

Coloproctol

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Zusammenfassung Ziel: Die lokale Exzision stellt die Standardbehandlung beim Morbus Bowen dar, kontrovers werden aber die Inzidenz synchroner und metachroner Karzinome sowie die Rolle eines Mapping-Verfahrens vor der Exzision betrachtet. Methodik: Die Krankenblätter von 25 Patienten, die zwischen 1978 und 2001 wegen eines perianalen Morbus Bowen behandelt worden waren, wurden retrospektiv ausgewertet. Ergebnisse: Die Untersuchung umfasste elf Männer und 14 Frauen mit einem Durchschnittsalter von 47,9 ± 14,9 Jahren zum Zeitpunkt der Diagnose. Bei der Mehrzahl der Patienten (72%) erfolgten Biopsien aufgrund von Symptomen. Dazu gehörten Pruritus (56%), Raumforderungen (28%), Blutungen (24%) und Analschmerzen (4%). Durchschnittlich bestanden die Symptome 1,3 ± 0,5 Jahre vor der Diagnosestellung. Bei zwei Patienten lag ein mikroskopisches Erkrankungsstadium vor, das zufällig nach Hämorrhoidektomie entdeckt worden war. Bei ihnen erfolgte keine weitere Behandlung. 23 Patienten unterzogen sich einer weiten lokalen Exzision; bei 19 von ihnen (83%) war ein formelles Mapping-Verfahren durchgeführt worden. Bei der abschließenden pathologischen Aufarbeitung wiesen 23 Patienten (92%) erkrankungsfreie Ränder auf. Es kam zu drei Rezidiven (Durchschnittszeitraum bis zum Rezidiv 2,0 ± 1,0 Jahre); dazu gehörten die beiden Patienten mit positiven Schnitträndern nach weiter Exzision (einer nach Mapping) und ein Patient, der nach dem Mapping erkrankungsfreie Schnittränder aufwies. Bei fünf Patienten (20%) wurden weitere Karzinome entdeckt (ein Sigmakarzinom, vier Vulvakarzinome). Bei der Nachuntersuchung waren 24 Patienten am Leben ohne Zeichen eines Morbus Bowen, ein Patient war sekundär nach Sigmakarzinom verstorben, aber ohne Hinweis auf einen Morbus Bowen. Schlussfolgerungen: Die weite Exzision eines perianalen Morbus Bowen führt zu exzellenter lokaler Kontrolle, obwohl dies in hohem Maße von tumorfreien Schnittcoloproctology coloproctology 2005; AbstractPurpose: Local excision is standard treatment for Bowen's disease, but controversy exists over the incidence of synchronous and metachronous cancers as well as the role of a preexcision mapping procedure.

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Conservative approach to the treatment of Bowen's disease of the anus

Cited by 21 publications

References 14 publications

Topical 5-Fluorouracil in the Management of Extensive Anal Bowen's Disease: A Preferred Approach

Topical 5-Fluorouracil in the Management of Extensive Anal Bowen's Disease: A Preferred Approach

Anal Bowen’s Disease: Retrospective Analysis of Five Cases

Ergebnisse, Risiko weiterer Malignome und Notwendigkeit formaler Mapping-Verfahren bei Patienten mit perianalem Morbus Bowen*

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