Conservative surgery and adjuvant radiation therapy in the management of adult soft tissue sarcoma of the extremities: Clinical and radiobiological results

Mundt, Arno J.; Awan, A.; Sibley, Gregory S.; Simon, Michael A.; Rubin, Steven J.; Samuels, Brian L.; Wong, William; Beckett, Michael A.; Vijayakumar, Srinivasan; Weichselbaum, Ralph R.

doi:10.1016/0360-3016(95)00111-b

Cited by 135 publications

(82 citation statements)

References 44 publications

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“…The results of the present study emphasize that even for radioresistant tumors, clinical responses of grid therapy may vary with the SF2 value. Some authors 25 , 30 have reported that tumors with different histology may have different SF2 values. Also, they have noted that, for a given tumor with a specific histology, there may be different radiosensitivity characteristics at different anatomical sites.…”

Section: Discussionmentioning

confidence: 99%

Is grid therapy useful for all tumors and every grid block design?

Gholami

Nedaie

Longo

et al. 2016

J Applied Clin Med Phys

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Grid therapy is a treatment technique that has been introduced for patients with advanced bulky tumors. The purpose of this study is to investigate the effect of the radiation sensitivity of the tumors and the design of the grid blocks on the clinical response of grid therapy. The Monte Carlo simulation technique is used to determine the dose distribution through a grid block that was used for a Varian 2100C linear accelerator. From the simulated dose profiles, the therapeutic ratio (TR) and the equivalent uniform dose (EUD) for different types of tumors with respect to their radiation sensitivities were calculated. These calculations were performed using the linear quadratic (LQ) and the Hug‐Kellerer (H‐K) models. The results of these calculations have been validated by comparison with the clinical responses of 232 patients from different publications, who were treated with grid therapy. These published results for different tumor types were used to examine the correlation between tumor radiosensitivity and the clinical response of grid therapy. Moreover, the influence of grid design on their clinical responses was investigated by using Monte Carlo simulations of grid blocks with different hole diameters and different center‐to‐center spacing. The results of the theoretical models and clinical data indicated higher clinical responses for the grid therapy on the patients with more radioresistant tumors. The differences between TR values for radioresistant cells and radiosensitive cells at 20 Gy and 10 Gy doses were up to 50% and 30%, respectively. Interestingly, the differences between the TR values with LQ model and H‐K model were less than 4%. Moreover, the results from the Monte Carlo studies showed that grid blocks with a hole diameters of 1.0 cm and 1.25 cm may lead to about 19% higher TR relative to the grids with hole diameters smaller than 1.0 cm or larger than 1.25 cm (with 95% confidence interval). In summary, the results of this study indicate that grid therapy is more effective for tumors with radioresistant characteristics than radiosensitive tumors.PACS number(s): 87.55.‐x

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Section: Discussionmentioning

confidence: 99%

Is grid therapy useful for all tumors and every grid block design?

Gholami

Nedaie

Longo

et al. 2016

J Applied Clin Med Phys

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show abstract

“…Generally, liposarcomas have higher local control rate than MFH, and synovial sarcomas are somewhere in between (6,11,13,17). The patient populations analysed are small, however, and liposarcoma, for example, is a highly heterogeneous disease, and it has to be emphasized that the outcome is greatly determined by its histologic subtype (14).…”

Section: Prognostic and Predictive Factorsmentioning

confidence: 99%

“…Many other studies that include miscellaneous anatomic sites are reported and emphasize various aspects of the sarcoma treatment, but do not add any clear evidence relating to the benefits of adjuvant radiotherapy (3,5,9,11,13,14,26).…”

Section: Prognostic and Predictive Factorsmentioning

confidence: 99%

A Systematic Overview of Radiation Therapy Effects in Soft Tissue Sarcomas

2003

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“…Overall, the percentage of patients ambulating without assisting devices and with mild or no pain was 84%. Mundt et al ( 1995) reviewed the outcome of 64 adult patients with soft tissue sarcoma of the extremities who underwent conservative surgery and radiotherapy. With an initial margin for the radiation field of less than 5 em, the local control rates were inferior.…”

Section: Managementmentioning

confidence: 99%

Radiotherapy in soft tissue sacoma of the extremities

Ngan

1997

Acta Orthopaedica Scandinavica

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Conservative surgery and adjuvant radiation therapy in the management of adult soft tissue sarcoma of the extremities: Clinical and radiobiological results

Cited by 135 publications

References 44 publications

Is grid therapy useful for all tumors and every grid block design?

Is grid therapy useful for all tumors and every grid block design?

A Systematic Overview of Radiation Therapy Effects in Soft Tissue Sarcomas

Radiotherapy in soft tissue sacoma of the extremities

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