Conservative surgery for borderline ovarian tumors: A review

Tinelli, Andrea; Tinelli, Andrea; Tinelli, F G; Cicinelli, Ettore; Malvasi, Antonio

doi:10.1016/j.ygyno.2005.09.021

Cited by 157 publications

(125 citation statements)

References 56 publications

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“…Thus, if a BOT has been diagnosed with no invasive implants, after an intensive patient consultation, the following procedure can be chosen: a detailed exploration of the abdomen, a peritoneal lavage, peritoneal biopsies from all regions of the abdomen, a unilateral salpingo-oophorectomy (USO), an omentectomy and in addition for mucinous BOT the appendectomy (Schmalfeldt and Pfisterer, 2007). According to current studies evaluating conservative surgery in this group, high conception rates were achieved after a simple ovarian cystectomy (Longacre et al, 2005;Marcickiewicz and Brannstrom, 2006;Tinelli et al, 2006;Yinon et al, 2007), but the high risk of local recurrence of up to 75% still limited the routine implementation (Suh-Burgmann, 2006). Results of cystectomy for BOT suggest a higher risk of intraoperative cyst rupture and of recurrence when compared with USO or BSO (Poncelet et al, 2006;Yokoyama et al, 2006).…”

Section: Surgical Therapymentioning

confidence: 99%

“…Thus, the borderline tumour -in contrast to that of an invasive ovarian carcinoma -has generally had an excellent prognosis (Sehouli et al, 2005a, b;Tinelli et al, 2006;Skirnisdottir et al, 2008). Borderline tumours of the ovary constitute 8 -10% of all ovarian tumours.…”

mentioning

confidence: 99%

“…Borderline tumours of the ovary constitute 8 -10% of all ovarian tumours. Having an incidence of 1.8 -4.8 out of 100 000 women per year, they belong to the seldom 'non-benign' epithelial ovarian tumours (Hart, 2005;Tinelli et al, 2006;Wong et al, 2007). In contrast to the case of ovarian carcinomas, most of the patients are diagnosed at an early stage I (Gotlieb et al, 2005;Yokoyama et al, 2006;Cusido et al, 2007).…”

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confidence: 99%

“…Although most part of BOT therapy was strongly oriented towards the ovarian cancer treatment (Suh-Burgmann, 2006;Tinelli et al, 2006;Cadron et al, 2007), adjuvant systemic chemotherapy is nowadays not generally indicated (Boran et al, 2005;Sehouli et al, 2005a, b;Romagnolo et al, 2006;Wong et al, 2007;Yinon et al, 2007).…”

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confidence: 99%

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Clinical management of borderline tumours of the ovary: results of a multicentre survey of 323 clinics in Germany

Coumbos¹,

Sehouli

Chekerov

et al. 2009

Br J Cancer

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The aim of this survey was to analyse the standard of care in diagnostic, surgery, chemotherapy and aftercare management for patients with borderline tumours of the ovary (BOTs) in Germany. A structured questionnaire comprising different dimensions was sent to all 1114 gynaecological departments. The questionnaire could be returned anonymously. The overall response rate was 29.0% (323 departments). Most departments were on secondary care (71.8%), tertiary care (23.2%) or university hospital (5.0%) level. Most clinicians performed not more than five BOT operations (89.2%) per year. Most departments (93.2%) used in addition to classical bimanual examination and vaginal ultrasound, tumour marker CA-125 detection, CT scan, MRI or PET-CT techniques. Departments in university and tertiary care hospitals performed more often a fresh frozen section (87 vs 64%). In young women, clinicians performed much seldom unilateral salpingo-oophorectomy (92%) and only in 53% biopsies of the contralateral ovary. Generally, biopsies of the contralateral ovary were performed in 4 -53% of the patients. Chemotherapy was mostly favoured in 'high-risk' patients with tumour residual, microinvasion or invasive implants. Thus, a high grade of insecurity in diagnostic and therapy of BOT exists in some gynaecological departments and underlines the need for more educational and study activities.

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Section: Surgical Therapymentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Clinical management of borderline tumours of the ovary: results of a multicentre survey of 323 clinics in Germany

Coumbos¹,

Sehouli

Chekerov

et al. 2009

Br J Cancer

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“…Protection of fertility by preserving the uterus and contralateral ovary is preferable for young patients (Karimi Zarchi et al, 2011). Unilateral oophorectomy or cystectomy are safe options for the stage I disease if careful follow-up of the patient is possible (Tinelli et al, 2006;Yinon et al, 2007;Park et al, 2009). However, the recurrence rate is 12%-58% after cystectomy (Trope et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Is Target Oriented Surgery Sufficient with Borderline Ovarian Tumors? - Role of Accompanying Pathologies

Güngör

Cetinkaya²,

Yalçin³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: There are limited data in the literature related to concomitant genital or extra-genital organ pathologies in patients with borderline ovarian tumors (BOTs). The aim of this study was to evaluate our experience with 183 patients to draw attention to the accompanying organ pathologies with BOTs. Materials and Methods: One hundred eighty-three patients with BOTs, diagnosed and/or treated in our center between January of 2000 and March of 2013 were evaluated retrospectively. Data related to age, tumor histology, lesion side, disease stage, accompanying incidental ipsilateral and/or contralateral ovarian pathologies, treatment approaches, and follow-up periods were investigated. Incidental gynecologic and non-gynecologic concomitant organ pathologies were also recorded. Results: The mean age at diagnosis was 40.6 years (range: 17-78). Ninetyfive patients (51%) were ≤40 years. A hundred and forty-seven patients (80%) were at stage IA of the disease. The most common type of BOT was serous in histology. Non-invasive tumor implants were diagnosed in 4% and uterine involvement was found 2% among patients who underwent hysterectomies. There were 12 patients with positive peritoneal washings. Only 17 and 84 patients respectively had concomitant ipsilateral and concomitant contralateral incidental ovarian pathologies. The most common type of uterine, appendicular and omental pathologies were chronic cervicitis, lymphoid hyperplasia and chronic inflammatory reaction. Conclusions: According to our findings most of accompanying pathologies for BOT are benign in nature. Nevertheless, there were additional malignant diseases necessitating further therapy. We emphasize the importance of the evaluation of all abdominal organs during surgery.

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Borderline Tumors of the Ovary

Crane

Thaker

2017

Textbook of Uncommon Cancer

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Conservative surgery for borderline ovarian tumors: A review

Cited by 157 publications

References 56 publications

Clinical management of borderline tumours of the ovary: results of a multicentre survey of 323 clinics in Germany

Clinical management of borderline tumours of the ovary: results of a multicentre survey of 323 clinics in Germany

Is Target Oriented Surgery Sufficient with Borderline Ovarian Tumors? - Role of Accompanying Pathologies

Borderline Tumors of the Ovary

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