Considerations About Pollen Used for the Production of Allergen Extracts

Codina, Rosa; Crenshaw, Rodger C.; Lockey, Richard F.

doi:10.1016/j.jaip.2015.04.003

Cited by 10 publications

(4 citation statements)

References 30 publications

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“…Plant pollen present in the air can cause various allergic reactions in humans, with symptoms ranging from nasal congestion, sneezing, and eye irritation to respiratory distress, asthma episodes and so on . In certain situations allergic reactions can aggravate other pathologies and cause death.…”

Section: Introductionmentioning

confidence: 99%

Degradation of pollen on nanofunctionalized photocatalytic materials

Sapiña

Jiménez-Relinque

Nevshupa

et al. 2016

J of Chemical Tech & Biotech

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Section: Introductionmentioning

confidence: 99%

Degradation of pollen on nanofunctionalized photocatalytic materials

Sapiña

Jiménez-Relinque

Nevshupa

et al. 2016

J of Chemical Tech & Biotech

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“…It was speculated that some of these reports were relatively old and the allergen extracts used for AIT were not well-purified, which might lead to the formation of immune complexes and the development of the disease [ 8 ]. The quality of allergen extracts has been improving due to the progress of purification and standardization technologies, thereby indicating that this risk may have been relatively reduced in recent years [ 27 ]. In this study, many patients with RADs were able to continue AIT and did not experience worsening of RAD activity.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness and safety of allergen immunotherapy in patients with allergic rhinitis complicated by rheumatic autoimmune diseases: a case series study

Fujioka

Kasahara

Kida

et al. 2022

Allergy Asthma Clin Immunol

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Background Allergen immunotherapy (AIT) is the only treatment that has modified the natural history of allergic diseases. However, since its overall effect on the immune system has not been elucidated, AIT is either absolutely or relatively contraindicated in patients with rheumatic autoimmune diseases (RADs). Therefore, there have been no long-term observations of patients with RADs receiving AIT; thus, the effectiveness and safety of AIT in these patients remain unclear. Methods This was a single-center retrospective observational study. RAD patients receiving AIT for allergic rhinitis at our institution were selected. Changes in the activity of RAD patients were investigated for 2 years from baseline, including those who discontinued AIT. The effectiveness of AIT was also investigated using the Japan Allergic Rhinitis Standard Quality of Life Questionnaire. Results Thirteen patients with RADs were enrolled in the study. All patients received sublingual immunotherapy, of which four discontinued AIT owing to adverse events. Among all patients, the symptoms of RADs in three patients worsened during the observation period; however, none of them were causally related to AIT. Most of the adverse events associated with AIT were mild, in which only one patient required drug intervention due to worsening rhinitis symptoms. In the nine patients who were able to continue AIT, their eye and nasal symptom scores showed a significant improvement from 1.67 (1.5–2.0) at baseline to 0.67 (0–1.17) in the 2nd year of treatment (p = 0.0141). Conclusions AIT is a safe and effective treatment modality for patients with allergic rhinitis complicated by RADs.

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“…Identification of the potent local allergens in each area is important and emphasizes the diagnostic value of the skin prick test. In addition, the types and amounts of allergenic components in plants and food are affected by geo-climatic and cultivation factors (15)(16)(17); therefore, the extract source is important, and several countries have started producing domestic extracts from local resources (18,19). Regarding the importance of allergenic extracts' quality and potency, and as the first step in producing domestic extracts in Iran, the aim of this study was to evaluate the safety and efficacy of 43 food and inhalant allergenic extracts prepared from domestic source material by the Sensitive Diagnostic Company of Iran.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of The Safety and Efficacy of Newly Developed Domestic Allergenic Extracts for Skin Prick Testing

et al. 2021

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Background: Allergic disorders are common health problems worldwide with significant socio-economic impacts. The best diagnostic method using allergenic extract is the skin prick test. Regarding the effects of geo-climatic factors and allergenic extract source material quality, the aim of study was to determine the safety and efficacy of some in-house-developed allergenic extracts. Methods: Forty-five different allergenic extracts, including common regional pollen, foods, and dog and cat hair, as well as positive and negative extracts, were prepared from domestic sources using optimum extraction methods. All extracts passed stability and sterility testing, and sterile final products containing 50% glycerin in 10 and 20 w/v concentrations were used. Skin prick testing was performed on volunteers and immediate or late side effects were recorded. Results: In total, 56 students (mean age: 21.2±2.3y, M/F ratio: 1.07) participated in this study. For inhalant allergens, all extracts except dog hair extract caused positive responses. Salsola kali (Russian thistle) and Fraxinus velutina (ash tree) were the most common grass and tree pollen extracts, respectively. Of 18 different food extracts, five, including egg white, tomato, fig, melon, and green pepper caused skin reactivity in only one person. No participant reported any immediate or late side effects, including large local reaction or systemic response. Conclusions:The result of the current study confirmed the safety of all our in-house-developed allergenic extracts. Regarding efficacy, almost all inhalant and five food allergens caused positive skin responses.

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Considerations About Pollen Used for the Production of Allergen Extracts

Cited by 10 publications

References 30 publications

Degradation of pollen on nanofunctionalized photocatalytic materials

Degradation of pollen on nanofunctionalized photocatalytic materials

Effectiveness and safety of allergen immunotherapy in patients with allergic rhinitis complicated by rheumatic autoimmune diseases: a case series study

Evaluation of The Safety and Efficacy of Newly Developed Domestic Allergenic Extracts for Skin Prick Testing

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