Considerations for Optimal Implementation of Radiation Therapy Into Multidisciplinary Care for Patients With Sarcoma

Spraker, Matthew B.

doi:10.1016/j.prro.2021.08.015

Cited by 2 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, radiotherapy is only recommended for preoperative or postoperative treatment of locally resectable STS to reduce the rate of recurrence. [85][86][87][88] Immunotherapy is marginalized and is only considered to have some efficacy against a few sarcoma subtypes. 87,89,90 This, together with the rarity of STS, ultimately leads to a scarcity of studies on the effect of immunoradiotherapy on STS compared to other cancers.…”

Section: Current Research Evidence On Sarcomasmentioning

confidence: 99%

Immunotherapy Plus Radiotherapy for the Treatment of Sarcomas: Is There a Potential for Synergism?

Wang¹,

Ge²,

Tian³

2023

OTT

View full text Add to dashboard Cite

Soft tissue sarcoma (STS) is a highly heterogeneous malignant tumor derived from mesenchymal tissue. Advanced STS has a poor response to the current anti-cancer therapeutic options, with a median overall survival of less than two years. Thus, new and more effective treatment methods for STS are needed. Increasing evidence has shown that immunotherapy and radiotherapy have synergistic therapeutic effects against malignant tumors. In addition, immunoradiotherapy has yielded positive results in clinical trials for various cancers. In this review, we discuss the synergistic mechanism of immunoradiotherapy in cancer treatment and the application of this combined regimen for the treatment of several cancers. In addition, we summarize the existing evidence on the use of immunoradiotherapy for the treatment of STS and the relevant clinical trials that are currently ongoing. Furthermore, we identify challenges in the use of immunoradiotherapy for the treatment of sarcomas and propose methods and precautions for overcoming these challenges. Lastly, we propose clinical research strategies and future research directions to help in the research and treatment of STS.

show abstract

Section: Current Research Evidence On Sarcomasmentioning

confidence: 99%

Immunotherapy Plus Radiotherapy for the Treatment of Sarcomas: Is There a Potential for Synergism?

Wang¹,

Ge²,

Tian³

2023

OTT

View full text Add to dashboard Cite

show abstract

“…Radiation therapy's primary role in STS is to improve local control in conjunction with surgery. In general, radiation is recommended to be part of the treatment regimen of patients at high risk of local recurrence, such as in large, high-grade tumors or those with a concern for positive margins after surgery [5]. Pre-operative radiation fields are generally smaller with a more readily defined target in conventional computed tomography (CT) imaging compared to post-operative fields.…”

Section: Role Of Radiation For Soft Tissue Sarcomasmentioning

confidence: 99%

The Role of MRI-Guided Radiotherapy for Soft Tissue Sarcomas

Blitzer

Yadav

Morris

2022

JCM

View full text Add to dashboard Cite

Soft tissue sarcomas (STS) are a rare class of tumors that originate from mesenchymal tissues and occur most frequently in the extremities, trunk, and retroperitoneum. Surgical resection with R0 margins is the primary curative treatment for most localized STS. In this setting, radiation therapy is used either pre-operatively or post-operatively to reduce the rate of local recurrence. Modern pre- or post-operative radiation therapy rely on the use of MRI sequences to guide target delineation during treatment planning. MRI-guided radiotherapy also offers unique advantages over CT-guided approaches in differentiating STS from surrounding normal soft tissues and enabling better identification of target volumes on daily imaging. For patients with unresectable STS, radiation therapy may offer the best chance for local tumor control. However, most STS are relatively radioresistant with modest rates of local control achieved using conventionally fractionated radiation. Specialized techniques such as hypofractionated radiation may allow for dose intensification and may increase rates of local control for STS. In these settings, MRI becomes even more critical for the delineation of targets and organs at risk and management of tumor and organ at risk motion during and between radiotherapy treatment fractions.

show abstract

Considerations for Optimal Implementation of Radiation Therapy Into Multidisciplinary Care for Patients With Sarcoma

Cited by 2 publications

References 10 publications

Immunotherapy Plus Radiotherapy for the Treatment of Sarcomas: Is There a Potential for Synergism?

Immunotherapy Plus Radiotherapy for the Treatment of Sarcomas: Is There a Potential for Synergism?

The Role of MRI-Guided Radiotherapy for Soft Tissue Sarcomas

Contact Info

Product

Resources

About