Consistent associations between measures of psychological stress and CMV antibody levels in a large occupational sample

Rector, Jerrald L.; Dowd, Jennifer Beam; Loerbroks, Adrian; Burns, Victoria E.; Moss, Paul; Jarczok, Marc N.; Stalder, Tobias; Hoffman, Kristina; Fischer, Joachim E.; Bosch, Jos A.

doi:10.1016/j.bbi.2014.01.012

Cited by 74 publications

(52 citation statements)

References 113 publications

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“…In 2014, Rector et al reported associations between measures of psychological well-being (depression, vital exhaustion, and poorer mental health) with higher CMV antibodies in an occupational cohort in Germany, and these associations were shown to be more robust among those of lower socioeconomic status (Rector et al 2014). Together, these studies indicate that socioeconomic status and other psychosocial stressors may modify CMV IgG antibody response in humans.…”

Section: Social and Economic Determinants That Influence CMV Epidemiomentioning

confidence: 64%

“…In response to exposure to stressors, human immunity may be altered, providing an opportunity for CMV to replicate and circulate, in turn inducing production of CMV-specific IgG antibodies (Rector et al 2014). For these reasons, higher CMV IgG antibody levels have been used as a surrogate measure of stress-related altered cell-mediated immunity in several studies (Segerstrom and Miller 2004).…”

Section: Social and Economic Determinants That Influence CMV Epidemiomentioning

confidence: 99%

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How does cytomegalovirus factor into diseases of aging and vaccine responses, and by what mechanisms?

2017

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Cytomegalovirus (CMV) is an important pathogen for both clinical and population settings. There is a growing body of research implicating CMV in multiple health outcomes across the life course. At the same time, there is mounting evidence that individuals living in poverty are more likely to be exposed to CMV and more likely to experience many of the chronic conditions for which CMV has been implicated. Further research on the causal role of CMV for health and wellbeing is needed. However, the strong evidence implicating CMV in type 2 diabetes, autoimmunity, cancer, cardiovascular disease, vaccination, and age-related alterations in immune function warrants clinical and public health action. This imperative is even higher among individuals living in socioeconomically disadvantaged settings and those exposed to high levels of chronic psychosocial stress.

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Section: Social and Economic Determinants That Influence CMV Epidemiomentioning

confidence: 64%

Section: Social and Economic Determinants That Influence CMV Epidemiomentioning

confidence: 99%

How does cytomegalovirus factor into diseases of aging and vaccine responses, and by what mechanisms?

2017

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“…A growing body of research has found that depression,(Haeri et al, 2011; Rector et al, 2014; Zhu et al, 2013) consistent with other forms of psychosocial distress (e.g. attachment anxiety,(Fagundes et al, 2014) psychosocial stress,(Glaser et al, 1985; Glaser et al, 1994) and exposure to adverse life events(McDade et al, 2000)), is also be associated with reactivation of latent herpes viruses, including the Epstein-Barr virus (EBV) – a latent virus linked to certain autoimmune disorders,(Niller et al, 2008) cancer(Li et al, 2016) and athersclerosis.…”

Section: 0 Introductionmentioning

confidence: 99%

Depressive symptoms are associated with salivary shedding of Epstein-Barr virus in female adolescents: The role of sex differences

Ford

Stowe

2017

Psychoneuroendocrinology

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Background Adolescent females have a higher prevalence of depression in comparison to their male peers - a disparity that has been increasing over the past decade. Depression is of concern as it is associated with chronic disease and to immune dysregulation, which may be one mechanism linking depression to future pathology. This study examined the extent to which sex moderated the association between depressive symptoms and immune dysregulation during adolescence using Epstein-Barr virus (EBV) reactivation, a biomarker of cellular immune response, as a model. Methods A representative community sample of 259 female and 279 male adolescents aged 11 to 17 years who were EBV IgG positive were examined. Trained interviewers collected the data during two home visits, one week apart. Depressive symptoms were measured at the first visit using the 9 item short-form of the Center for Epidemiologic Studies-Depression scale. EBV biomarkers were collected via saliva at the second visit and included a qualitative measure of EBV viral capsid antigen immunoglobulin G to assess prior EBV infection and a quantitative measure of EBV DNA to assess the number of viral copies shed in the saliva. Results In multivariable logistic regression analyses, increasing depressive symptoms were significantly associated with salivary shedding of EBV DNA for adolescent females only (logit=0.66, se=0.30, p<0.05), and the interaction between sex and depressive symptoms on salivary shedding of EBV DNA was statistically significant (logit= −1.19, se=0.42, p<0.01). Sensitivity analyses were conducted in which sex was examined as a moderator in the relationship between depressive symptoms and salivary EBV DNA quantitative copies via Tobit regression; results were consistent with the presented findings. Conclusions Depressive symptoms are associated with EBV reactivation among EBV positive female adolescents, but not males. Future research is needed to examine EBV reactivation in female adolescents as a mechanism linking depression to future chronic disease and the role of sex hormones in explaining sex differences in the relationship between depressive symptoms and EBV reactivation.

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“…Reactivation has, in turn, been hypothesized to trigger increased production of antibodies specific for such pathogens (Dowd et al, 2008(Dowd et al, , 2012Christian et al, 2012;Rector et al, 2014), and contribute to elevated levels of circulating pro-inflammatory cytokines such as Creactive protein and interleukin-6 (Nazmi et al, 2010;Bennett et al, 2012). To our knowledge no studies have examined the association between maternal infection with herpesviruses and offspring anxiety disorders, however, prenatal exposure to such pathogens have been implicated in the etiology of other neuropsychiatric disorders such as schizophrenia (Buka et al, 2008).…”

Section: Introductionmentioning

confidence: 92%

Use of Archived Neonatal Bloodspots for Examining Associations between Prenatal Exposure to Potentially Traumatic or Stressful Life Events, Maternal Herpesvirus Infection and Lifetime History of Generalized Anxiety Disorder in Offspring

Simanek

Uddin

Yolken³

et al. 2016

Front. Environ. Sci.

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Background: Lifetime prevalence of anxiety disorders is over 30% among U.S. adolescents, warranting further investigation into early life risk factors for such conditions. We conducted a pilot study to examine the role that maternal herpesvirus infection may play in the pathway between maternal trauma and stress during pregnancy and offspring generalized anxiety disorder (GAD).Methods: Participants included 69 women in the Detroit Neighborhood Health Study with data on past exposure to 19 potentially traumatic (PTEs) and 9 stressful life events (SLEs). Lifetime history of GAD in the youngest biologic child between 6 and 17 years old born in Michigan (i.e., index child) of each woman was ascertained via the Diagnostic Interview Schedule for Children, 4th edition, parent version. We obtained written informed consent from participants for retrieval of archived neonatal bloodspot samples corresponding to their index child from the Michigan Neonatal Biobank (MNB) and testing of these samples for markers of maternal herpes simplex virus (HSV)-1 and cytomegalovirus (CMV) seropositivity. Logistic regression was used to examine the association between maternal PTEs or SLEs during pregnancy and offspring GAD.Results: A total of 18.1 and 31.9% of women experienced ≥1 PTE or SLE during pregnancy, respectively, and 10.8% of offspring met the criteria for lifetime history of GAD. We obtained maternal consent for retrieval of and tested bloodspot samples corresponding to the index child of 22 women (38.0%), of which 4.5 and 40.9% were seropositive for HSV-1 and CMV, respectively. We observed positive, although not statistically significant associations between ≥1 PTE or SLE during pregnancy and offspring lifetime history of GAD. While a greater proportion of offspring with lifetime Simanek et al. Prenatal Trauma, Herpesviruses Offspring GAD history of GAD were born to women seropositive for CMV and HSV-1, compared to those without lifetime history, these differences were not statistically significant and we did not further examine the mediating role of maternal herpesvirus seropositivity in this pathway. Conclusion:Findings from this study support the feasibility of utilizing neonatal bloodspots archived in the MNB to examine the role of herpesviruses as mediators between maternal trauma or stress during pregnancy and offspring anxiety disorders in larger Michigan cohorts.

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Consistent associations between measures of psychological stress and CMV antibody levels in a large occupational sample

Cited by 74 publications

References 113 publications

How does cytomegalovirus factor into diseases of aging and vaccine responses, and by what mechanisms?

How does cytomegalovirus factor into diseases of aging and vaccine responses, and by what mechanisms?

Depressive symptoms are associated with salivary shedding of Epstein-Barr virus in female adolescents: The role of sex differences

Use of Archived Neonatal Bloodspots for Examining Associations between Prenatal Exposure to Potentially Traumatic or Stressful Life Events, Maternal Herpesvirus Infection and Lifetime History of Generalized Anxiety Disorder in Offspring

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