1996
DOI: 10.1006/jsre.1996.0117
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Consistent Hepatic Metastasis of Human Colorectal Cancer in Severe Combined Immunodeficient Mice

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Cited by 2 publications
(3 citation statements)
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“…Human colorectal cancer will grow and propagate as primary tumors in the subcutaneous tissue and as metastatic tumors in the gonad fat pad of the SCID mouse. 1,2 Following surgical removal of colorectal tumors and confirmation of malignancy the tissue was implanted subcutaneously in SCID mice. The mice were injected intraperitoneally with Nef peptide at doses ranging from 20 ng to 2 µg biweekly.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Human colorectal cancer will grow and propagate as primary tumors in the subcutaneous tissue and as metastatic tumors in the gonad fat pad of the SCID mouse. 1,2 Following surgical removal of colorectal tumors and confirmation of malignancy the tissue was implanted subcutaneously in SCID mice. The mice were injected intraperitoneally with Nef peptide at doses ranging from 20 ng to 2 µg biweekly.…”
Section: Resultsmentioning
confidence: 99%
“…Human colorectal tumors once implanted will propagate and metastasize in the severe combined immunodeficient (SCID) mouse. 1,2 Furthermore, these tumors maintain their human genetic make up through multiple repassages. This model has proven to be a useful tool to evaluate human cancers, such as colorectal, for their growth patterns, cell surface receptors, and the therapeutic effects of antitumoral agents.…”
Section: Introductionmentioning
confidence: 99%
“…Primary tumor growth and metastasis of CRC to secondary organs can be inhibited through the actions of Nef-M1. A well developed model for producing hepatic metastasis from human surgical CRC specimens have been developed and reported by one of the authors (25). This will further enable assessment of Nef-M1 ability to inhibit metastasis of human CRC from a diverse group of patients.…”
Section: Discussionmentioning
confidence: 99%