Consolidative or palliative whole brain radiation for secondary CNS diffuse large B-Cell lymphoma

Walburn, Tyler; Grover, Natalie S; Shen, Colette J.; Ranganathan, Raghuveer; Dittus, Christopher; Beaven, Anne; Wang, Andrew Z.; Wang, Kyle

doi:10.1080/10428194.2020.1821014

Cited by 6 publications

(2 citation statements)

References 26 publications

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“…11 Whole brain RT has also been successful as a consolidative treatment modality for select patients, particularly those who are not eligible for transplant and/or have isolated CNS recurrences. 12 The data concerning the efficacy, safety, and optimal timing of RT pre-and post-CAR T-cell therapy infusion in patients with SCNSL is limited. 13 We aim to report our early experience of using RT in the bridging and salvage settings in SCNSL patients undergoing CAR Tcell therapy.…”

Section: Radiation Therapy As Bridging and Salvage Strategy Among Pat...mentioning

confidence: 99%

Radiation therapy as bridging and salvage strategy among patients with secondary central nervous system lymphoma undergoing CD19‐targeted chimeric antigen receptor T‐cell therapy

Ababneh,

Frigault,

et al. 2023

Hematological Oncology

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Section: Radiation Therapy As Bridging and Salvage Strategy Among Pat...mentioning

confidence: 99%

Radiation therapy as bridging and salvage strategy among patients with secondary central nervous system lymphoma undergoing CD19‐targeted chimeric antigen receptor T‐cell therapy

Ababneh,

Frigault,

et al. 2023

Hematological Oncology

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“…The results of this small study sample suggest that consolidative WBRT may improve long-term survival in SCNSL and could be a potential option for transplant ineligible patients or patients with CNS-only relapse. 16 Additionally, WBRT has been used as the stand-alone treatment in PCNSL with ORR of 90% and median OS of 11.6 months. 17 At the time of first CNS-only relapse, our patient was treated at an outside institution and underwent WBRT.…”

mentioning

confidence: 99%

Multiply Relapsed Secondary CNS Non-Germinal Center Diffuse Large B-Cell Lymphoma Successfully Treated with CNS-Centric Therapy

Fournier¹,

Kimbrough²,

Moustafa³

et al. 2023

JBM

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Secondary central nervous system involvement by systemic diffuse large B-cell lymphoma (DLBCL) carries a very poor prognosis. We present a female patient who had two episodes of intracerebral central nervous system (CNS)-only relapse of systemic non-germinal center diffuse large B-cell lymphoma (NGC-DLBCL). Her treatment at initial diagnosis consisted of induction with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) and intrathecal (IT) -methotrexate (MTX) followed by consolidation with autologous stem cell transplant (ASCT) after high-dose carmustine, etoposide, cytarabine, and melphalan (BEAM) chemotherapy. She had the first CNS-only relapse 1.5 years post-ASCT and received whole brain radiation therapy (WBRT). She developed the second intracerebral CNS-only relapse 2 years post-WBRT. A CNS-centric therapeutic approach with salvage chemoimmunotherapy incorporating rituximab, high-dose methotrexate (HD-MTX), high-dose cytarabine (HiDAC), and ibrutinib was utilized for her second CNS-only relapse. She underwent consolidation with a second ASCT following high-dose carmustine (BCNU) and thiotepa chemotherapy. Given her high risk of CNS recurrence, she was started on maintenance ibrutinib. To date, she has remained in complete remission for 3 years. In our experience, multiply relapsed secondary CNS lymphoma (SCNSL) with this response is very rare. We suggest one CNS-centric therapeutic approach that can potentially salvage patients with SCNSL who have not had prior exposure to adequate CNS-directed therapies but acknowledge that additional research is necessary to validate our findings.

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Advanced Stage Hodgkin and Diffuse Large B-Cell Lymphomas: Is There Still a Role for Consolidation Radiotherapy in the PET Era?

Levis,

Oertel

2025

Seminars in Radiation Oncology

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Consolidative or palliative whole brain radiation for secondary CNS diffuse large B-Cell lymphoma

Cited by 6 publications

References 26 publications

Radiation therapy as bridging and salvage strategy among patients with secondary central nervous system lymphoma undergoing CD19‐targeted chimeric antigen receptor T‐cell therapy

Radiation therapy as bridging and salvage strategy among patients with secondary central nervous system lymphoma undergoing CD19‐targeted chimeric antigen receptor T‐cell therapy

Multiply Relapsed Secondary CNS Non-Germinal Center Diffuse Large B-Cell Lymphoma Successfully Treated with CNS-Centric Therapy

Advanced Stage Hodgkin and Diffuse Large B-Cell Lymphomas: Is There Still a Role for Consolidation Radiotherapy in the PET Era?

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