Constipation and Intestinal Neuronal Dysplasia Type B: A Clinical Follow-up Study

Abstract

In young patients, constipation related to IND B can be treated successfully by conservative treatment regimens, including diet, laxatives, and prokinetic drugs.

Intestinal neuronal dysplasia type B: A still little known diagnosis for organic causes of intestinal chronic constipation

“…This wide variation may be attributable to the lack of consensus on the diagnostic criteria [6,31] . There is also an irregular geographical distribution; the highest rates of diagnosis are in Euro pean countries, which can be explained by the fact that the majority of the published research comes from this continent [32] . The latest published series by Taguchi et al [33] (2014) involved a retrospective multicenter study of cases of INDB in 167 centers in Japan from 2000 to 2009.…”

“…Patients with IND have been subjected to different treatments moda lities, that may vary from clinical management, to surgical procedures [57] . Clinical management includes dietary changes, laxatives and enemas [6,32] . Schimpl et al [32] (2004) reported satisfactory results in 80% of 105 patients treated with dietary changes, cisapride, laxatives and enemas, in a median follow up period of 7.2 years.…”

“…Clinical management includes dietary changes, laxatives and enemas [6,32] . Schimpl et al [32] (2004) reported satisfactory results in 80% of 105 patients treated with dietary changes, cisapride, laxatives and enemas, in a median follow up period of 7.2 years. Clinical management must follow the currently used guidelines for the treatment of intestinal chronic con stipation in children, including fecal desimpaction and laxatives [72] .…”

“…The results obtained with these different types of treatment are very discordant. Longterm followup studies are lacking and the available studies involve limited numbers of patients [32,57,75] . Thus, the available data nowadays still remains too scarce to establish a therapeutic guideline for INDB [32,57] .…”

“…Longterm followup studies are lacking and the available studies involve limited numbers of patients [32,57,75] . Thus, the available data nowadays still remains too scarce to establish a therapeutic guideline for INDB [32,57] . On the other hand, there is a real disease, with its own clinical manifestations and can not be classified only as an histopathological entity [75] .…”