Constipation and Laxative Herbs in Iranian Traditional Medicine

Abstract

Context: Constipation is one of the most prevalent gastrointestinal disorders and is characterized by stiffness of waste and difficult defecation. In modern medicine, different laxative drugs are used for the treatment of constipation, but they are not without side effects. Nonetheless, the appropriate use of herbal medicines can be beneficial for treating this disorder. Therefore, this study attempted to draw together some pharmacological and medical insights into the management of constipation through the use of Iranian traditional medicine (ITM). Evidence Acquisition: In this review article, we initially researched constipation and laxative herbs using some of the most famous ancient medical and pharmacological textbooks pertaining to Iranian medicine written from the 10 th to 18 th century AD. This includes The canon of medicine by Avicenna (10 th and 11 th centuries, Beirut publication), Makhzan-ol-advie by Aghili (18 th century, Tehran University of Medical Science Press), and Al-shamel by Gharashi (13 th century, Caltural foundation Publication). Then we extracted the names and laxative mechanisms of some herbs prescribed for constipation through ITM. Finally, a search of scientific databases such as PubMed and Google Scholar was performed to find related works concerning laxative mechanisms. Results: In ITM doctrine, laxatives are weak purgatives that lead to the defecation of waste from the gastrointestinal tract. From this perspective, laxative herbs can be classified into two groups based on their nature: laxative herbs with a hot nature cause the dilution and flowing of humors, but herbs with a cold nature function as laxatives due to their mucilage properties. Each of the laxatives was used in accordance with the primary reason for constipation. Conclusions:This study presents medical and pharmacological approaches in ITM for dealing with complications arising from constipation. Considering the optimistic results, these herbs can be used as a means of constipation management and further investigation into this area can potentially lead to the formulation of new drugs.

Comparative Evaluation between the LaxaPlus Barij® and Polyethylene Glycol (4000) in the Pediatric Functional Constipation in Children 2–15 Years Old

“…The effect of other medicinal plants, such as asparagus, borage, and Sapistan seeds has been confirmed in other studies as laxative plants in the treatment of constipation. [ 10 11 12 13 14 15 16 17 ] LaxaPlus Barij ® Syrup is an herbal medicine used to treat constipation. This syrup is prepared from the extract of jujube, rose, asparagus, violet flower, borage, quince seeds, and Cordia myxa fruit, which is used in traditional Iranian medicine.…”