Constituintes químicos de Sebastiania macrocarpa Muell. Arg. (Euphorbiaceae)

Lima, Michele A. A.; Lima, Jefferson Queiroz; Arriaga, Ângela M. C.; Andrade‐Neto, Manoel; Santiago, Gilvandete Maria Pinheiro; Bezerra, Beatriz Pinheiro; Fereira, Yana S.; Veras, Helenicy N. H.; Braz‐Filho, Raimundo

doi:10.1590/s0100-40422009000200015

Cited by 9 publications

(12 citation statements)

References 14 publications

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“…From the aerial parts of S. macrocarpa a mixture of steroids β-sitosterol and stigmasterol, gallic acid and scopoletin was isolated (Lima et al, 2009a). There were no studies reporting the content of total phenolic compounds and flavonoids in the S. hispida.…”

Section: Discussionmentioning

confidence: 99%

Wound-Healing potential of Sebastiania hispida (Mart.) Pax (Euphorbiaceae) ointment compared to low power laser in rats

et al. 2016

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Impaired wound healing represents a serious complication in some pathologies and the use of plant extracts has proved to improve tissue repair. The objectives of this study were to evaluate the healing potential of the ointment of Sebastiana hispida compared with Aluminum-Gallium Indium-Phosphide Laser (InGaAlP) in surgically induced wounds in rats and to perform the phytochemical analysis. The phytochemical analysis was performed in the classic way and also by HPLC. A controlled study was developed with 80 rats (200-250 g) in which a linear excision was performed in the dorsal region after shaving, measuring 2 cm × 1 cm (epidermis and dermis) exposing the muscle fascia. The rats were randomly divided into four groups of twenty animals each. The experimental groups (n = 5) were G1 (Saline); G2 (crude methanol plant extract 2% + Carbopol Gel 98%); G3 (crude methanol plant extract 2% + lanolin/vaseline) and G4 (laser). The incision healing processes were monitored during 3, 7, 14 and until 21 days after excision. The histologic parameters evaluated were Collagen fiber types, microscopic examination and neovascularization. There was a significant increase in the deposition of collagen fibers, as evidenced by a better organized epithelial tissue, keratinized and showing greater proliferation of new blood vessels in the inflammatory phase in the group treated with both the extract and laser. The results were correlated to the phenolic derivatives found after qualitative and quantitative analysis. These compounds were considered responsible for the healing process. The topical treatment with S. hispida leaves, in the two different formulations, was more effective than the application of the laser (Ingan ALP) 660 nm in the model used.Keywords: laser therapy, tissue repair, inflammatory cells, medicinal plants. Potencial cicatrizante da pomada de Sebastiania hispida (Mart.) Pax (Euphorbiaceae) comparado ao laser de baixa potência ResumoA cicatrização deficiente representa uma complicação grave em algumas patologias e o uso de extratos de plantas tem demonstrado melhora no processo de reparação tecidual. O objetivo deste estudo foi avaliar o potencial cicatrizante da pomada de Sebastiania hispida comparado ao Laser Indio Phosphide-Gallium-Aluminum (InGaAlP) em feridas cutâneas induzidas cirurgicamente em ratos e realizar analise fitoquímica. A análise fitoquímica foi via clássica e por CLAE. O experimento foi desenvolvido com 80 ratos (200-250 g), divididos aleatoriamente em quatro grupos (n = 5): G1 (salina); G2 (extrato bruto metanólico 2% + Carbopol Gel 98%); G3 (extrato bruto metanólico 2% + lanolina/ vaselina) e G4 (laser). Após a tricotomia da região dorsal realizou uma excisão linear, medindo 2 cm × 1 cm (epiderme e derme), expondo a fáscia muscular. Em sequência os tratamentos e o monitoramento do processo de cicatrização das feridas cirúrgicas ocorreu nos tempos de: 3, 7, 14 e até 21 dias após a excisão. Os parâmetros histológicos avaliadosBraz.

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Section: Discussionmentioning

confidence: 99%

Wound-Healing potential of Sebastiania hispida (Mart.) Pax (Euphorbiaceae) ointment compared to low power laser in rats

et al. 2016

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“…26 Tonantzitlolone A was also isolated from the aerial parts of Sebastania macrocarpa, another Euphorbiaceae species collected in Brazil. 27 In this paper are reported the LC-MS-guided isolation, structure elucidation, and anti-CHIKV properties of three known (1−3) and six new tonantzitlolones (4−9), tonantzitloic acid (10), and three new (11, 13, and 15) and two known tigliane diterpenes (12 and 14) isolated from the ethyl acetate extract of S. lineata leaves. The panel of viruses against which the antiviral activity of this compound class is studied was expanded with two additional members of the genus alphavirus (Sindbis virus: SINV; Semliki Forest virus: SFV), and for compounds 11−15 two members of the genus lentivirus (HIV-1 and HIV-2 viruses).…”

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confidence: 99%

Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata

et al. 2015

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In an effort to identify new potent and selective inhibitors of chikungunya virus and HIV-1 and HIV-2 virus replication, the endemic Mascarene species Stillingia lineata was investigated. LC/MS and bioassay-guided purification of the EtOAc leaf extract using a chikungunya virus-cell-based assay led to the isolation of six new (4-9) and three known (1-3) tonantzitlolones possessing the rare C20-flexibilane skeleton, along with tonantzitloic acid (10), a new linear diterpenoid, and three new (11, 13, and 15) and two known (12 and 14) tigliane-type diterpenoids. The planar structures of the new compounds and their relative configurations were determined by spectroscopic analysis, and their absolute configurations were determined through comparison with literature data and from biogenetic considerations. These compounds were investigated for selective antiviral activity against chikungunya virus (CHIKV), Semliki Forest virus, Sindbis virus, and, for compounds 11-15, the HIV-1 and HIV-2 viruses. Compounds 12-15 were found to be the most potent and are selective inhibitors of CHIKV, HIV-1, and HIV-2 replication. In particular, compound 14 inhibited CHIKV replication with an EC50 value of 1.2 μM on CHIKV and a selectivity index of >240, while compound 15 inhibited HIV-1 and HIV-2 with EC50 values of 0.043 and 0.018 μM, respectively. It was demonstrated further that potency and selectivity are sensitive to the substitution pattern on the tigliane skeleton. The cytotoxic activities of compounds 1-10 were evaluated against the HCT-116, MCF-7, and PC3 cancer cell lines.

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“…It is commonly used in powder form as an antiulcerative, antisyphilitic, diuretic, depurative, and stimulant (Pio Corrêa, 1984). Antiinflammatory, antibacterial and antifungal (Lima et al, 2009a) effects as well as leishmanicidal activity against Leishmania amazonensis promastigotes have also been reported (Bezerra et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of genotoxic and cytotoxic effects of antileishmanial extract from Julocroton triqueter (Euphorbiaceae)

Moreira¹,

Dias²,

Martins³

et al. 2013

Genet. Mol. Res.

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ABSTRACT.Julocroton triqueter extracts have antileishmanial activity; however, the effect on genetic stability has not been studied. We evaluated genotoxic and cell death induction potential (in vitro and in vivo) of J. triqueter var. triqueter hydroalcoholic extracts, as well as their antigenotoxic potential in vivo. The in vitro genotoxic studies were performed using human leukocytes at four different concentrations. For the in vivo tests, Swiss mice were treated with 125, 250 or 500 mg/kg of extract injected intraperitoneally. Antigenotoxic effects of the extract were measured before and after cyclophosphamide treatment. An absence of genotoxic effects was observed both in vitro and in vivo. In the antigenotoxic studies, no significant difference was observed between the treatments and the positive control, indicating that the extracts did not protect against Evaluation of genotoxic effects of antileishmanial extract damage caused by cyclophosphamide. Hydroalcoholic extracts of J. triqueter did not provoke DNA damage at concentrations and doses normally used for antileishmanial treatment; however, they reduced apoptotic cell death and induced necrotic cell death.

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Constituintes químicos de Sebastiania macrocarpa Muell. Arg. (Euphorbiaceae)

Cited by 9 publications

References 14 publications

Wound-Healing potential of Sebastiania hispida (Mart.) Pax (Euphorbiaceae) ointment compared to low power laser in rats

Wound-Healing potential of Sebastiania hispida (Mart.) Pax (Euphorbiaceae) ointment compared to low power laser in rats

Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata

Evaluation of genotoxic and cytotoxic effects of antileishmanial extract from Julocroton triqueter (Euphorbiaceae)

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