2022
DOI: 10.1111/hel.12917
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Constitutive programmed death ligand 1 expression protects gastric G‐cells from Helicobacter pylori–induced inflammation

Abstract: Introduction Gastric intestinal metaplasia (GIM) is a premalignant lesion, highly associated with Helicobacter pylori infection. Previous studies have shown that H. pylori is able to induce the expression of programmed death ligand 1 (PD‐L1), an inhibitory immune modulator, in gastric cells. Our aim was to investigate whether tissues from GIM patients may exploit PD‐L1 expression upon H. pylori infection to evade immunosurveillance. Methods Immunohistochemistry was performed for PD‐L1 and enteroendocrine marke… Show more

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