“…However, one amino acid substitution occurs in one of the three regions implicated in the interaction with IGF binding proteins (IGF-BPs). In fact, specific binding of human IGF-I to the type 1 IGF receptor 4,7,16,18,20,27,32,34 and plasma IGF binding proteins 1,14,20,42,43,45 is observed in all groups of fish studied (Agnatha, Chondrichthyes, Salmoniformes, Cypriniformes, and Perciformes). Moreover, human IGF-I exerts a biological effect in Chondrichthyes and different…”