2009
DOI: 10.1182/blood-2008-02-139725
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Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells

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Cited by 265 publications
(302 citation statements)
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“…In contrast, overexpression of N1ICD enhanced proliferation and cyclin expression but suppressed cleaved caspase-3 in purified vCTBs or CCTs. Notch-dependent survival operates through different mechanisms involving mammalian target of rapamycin (mTOR)-Akt-mediated suppression of p53 or activation of inhibitors of apoptosis such as XIAP (27,63). Expression of the latter was not affected by Notch1 in trophoblasts.…”
Section: Discussionmentioning
confidence: 99%
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“…In contrast, overexpression of N1ICD enhanced proliferation and cyclin expression but suppressed cleaved caspase-3 in purified vCTBs or CCTs. Notch-dependent survival operates through different mechanisms involving mammalian target of rapamycin (mTOR)-Akt-mediated suppression of p53 or activation of inhibitors of apoptosis such as XIAP (27,63). Expression of the latter was not affected by Notch1 in trophoblasts.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, cleaved caspase-3 decreased when Notch1 levels were highest, suggesting that the receptor could, at least partly, counteract CPT-induced apoptosis. Notch1 was shown to promote survival by inhibiting degradation of X-linked inhibitor of apoptosis (XIAP) (27). Stability of the latter, however, was not affected upon silencing of Notch1 in CTBs (SI Appendix, Fig.…”
Section: Notch1 Is Specifically Expressed In Progenitors Of the Extramentioning
confidence: 99%
“…7,8 By this approach, NOTCH1 mutations occurred in only 2 of 63 (3.2%) cMBL, with a prevalence that was significantly lower than that observed in a large CLL dataset (70 of 603, 11.6%) (P=0.050). In both cases, mutations were represented by a two bp frameshift deletion (c.7544_7545delCT) that represents the most recurrent (~80%) type of NOTCH1 mutation detectable in CLL (Figure 1).…”
Section: Analysis Of Notch1 Mutations In Monoclonal B-cell Lymphocytosismentioning
confidence: 75%
“…[4][5][6] Recently, two independent investigations of the CLL coding genome have revealed that activating mutations of the NOTCH1 proto-oncogene occur in approximately 10% CLL at diagnosis and their frequency increases in advanced disease phases, exemplified by the case of Richter syndrome. 7,8 Initial evidence suggests that NOTCH1 alterations might predict an unfavorable clinical outcome in CLL. The prevalence of NOTCH1 mutations in MBL is currently unknown.…”
Section: Analysis Of Notch1 Mutations In Monoclonal B-cell Lymphocytosismentioning
confidence: 99%
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