Constraining EEG-MEG Source Imaging with Statistical Neuroanatomy

Valdés, P.; Picton, Terry; Trujillo, N.; Bosch, J.; Aubert, Eduardo Henrik; Riera, Jorge J.; Biscay, Rolando J.; Carbonell, Félix; Barroso, E; Fernández, Antonio; Evans, Alan C.

doi:10.1016/s1053-8119(18)31468-x

Cited by 35 publications

(17 citation statements)

References 2 publications

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“…LORETA is a functional imaging technique belonging to a family of linear inverse solution procedures (Valdes et al, 1998) modeling 3D distributions of EEG sources (Pascual-Marqui et al, 2002). With respect to the dipole modeling of cortical sources, no a priori decision of the dipole position is required by the LORETA procedure.…”

Section: Methodsmentioning

confidence: 99%

Occipital sources of resting-state alpha rhythms are related to local gray matter density in subjects with amnesic mild cognitive impairment and Alzheimer's disease

Babiloni

Percio

Boccardi

et al. 2015

Neurobiology of Aging

106

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Occipital sources of resting state electroencephalographic (EEG) alpha rhythms are abnormal, at the group level, in patients with amnesic mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Here we evaluated the hypothesis that amplitude of these occipital sources is related to neurodegeneration in occipital lobe as measured by magnetic resonance imaging (MRI). Resting-state eyes-closed EEG rhythms were recorded in 45 healthy elderly (Nold), 100 MCI, and 90 AD subjects. Neurodegeneration of occipital lobe was indexed by weighted averages of gray matter density (GMD), estimated from structural MRIs. EEG rhythms of interest were alpha 1 (8–10.5 Hz) and alpha 2 (10.5–13 Hz). EEG cortical sources were estimated by low resolution brain electromagnetic tomography (LORETA). Results showed a positive correlation between occipital GMD and amplitude of occipital alpha 1 sources in Nold, MCI and AD subjects as a whole group (r=0.3, p=0.000004, N=235). Furthermore, there was a positive correlation between amplitude of occipital alpha 1 sources and cognitive status as revealed by Mini Mental State Evaluation (MMSE) score across all subjects (r=0.38, p=0.000001, N=235). Finally, amplitude of occipital alpha 1 sources allowed a moderate classification of individual Nold and AD subjects (sensitivity: 87.8%; specificity: 66.7%; area under the Receiver Operating Characteristic (ROC) curve: 0.81). These results suggest that the amplitude of occipital sources of resting state alpha rhythms is related to AD neurodegeneration in occipital lobe along pathological aging.

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Section: Methodsmentioning

confidence: 99%

Occipital sources of resting-state alpha rhythms are related to local gray matter density in subjects with amnesic mild cognitive impairment and Alzheimer's disease

Babiloni

Percio

Boccardi

et al. 2015

Neurobiology of Aging

106

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show abstract

“…Fourthly, LORETA is a functional imaging technique belonging to a family of linear inverse solution procedures like minimum norm solution, weighted minimum norm solution, or weighted resolution optimization [PascualMarqui et al, 1999;Phillips et al, 2002;Valdès et al, 1998;Yao and He, 2001]. These techniques model 3D distributions of EEG sources [Pascual-Marqui et al, 2002].…”

Section: Methodological Remarksmentioning

confidence: 99%

Cortical responses to consciousness of schematic emotional facial expressions: A high‐resolution EEG study

Babiloni¹,

Vecchio²,

Buffo³

et al. 2010

Human Brain Mapping

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Is conscious perception of emotional face expression related to enhanced cortical responses? Electroencephalographic data (112 channels) were recorded in 15 normal adults during the presentation of cue stimuli with neutral, happy or sad schematic faces (duration: "threshold time" inducing about 50% of correct recognitions), masking stimuli (2 s), and go stimuli with happy or sad schematic faces (0.5 s). The subjects clicked left (right) mouse button in response to go stimuli with happy (sad) faces. After the response, they said "seen" or "not seen" with reference to previous cue stimulus. Electroencephalographic data formed visual event-related potentials (ERPs). Cortical sources of ERPs were estimated by LORETA software. Reaction time to go stimuli was generally shorter during "seen" than "not seen" trials, possibly due to covert attention and awareness. The cue stimuli evoked four ERP components (posterior N100, N170, P200, and P300), which had similar peak latency in the "not seen" and "seen" ERPs. Only N170 amplitude showed differences in amplitude in the "seen" versus "not seen" ERPs. Compared to the "not seen" ERPs, the "seen" ones showed prefrontal, premotor, and posterior parietal sources of N170 higher in amplitude with the sad cue stimuli and lower in amplitude with the neutral and happy cue stimuli. These results suggest that nonconscious and conscious processing of schematic emotional facial expressions shares a similar temporal evolution of cortical activity, and conscious processing induces an early enhancement of bilateral cortical activity for the schematic sad facial expressions (N170).

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“…The EEG cross‐spectra were given as an input to the proper option of the original LORETA software for the EEG source analysis (Pascual‐Marqui & Michel, 1994, Pascual‐Marqui et al ., 1999, 2002). LORETA is a functional imaging technique belonging to a family of linear inverse solution procedures (Valdes et al ., 1998) modelling 3‐D distributions of the cortical source patterns generating scalp EEG data (Pascual‐Marqui et al ., 2002). With respect to the dipole modelling of cortical sources, no a priori decision of the dipole position is required by the investigators in LORETA estimation.…”

Section: Methodsmentioning

confidence: 99%

“…As a preliminary control hypothesis, we selected the cortical sources of EEG rhythms that correlated with subjects' global cognitive status as revealed by MMSE. The cortical generators of EEG rhythms were estimated by low‐resolution brain electromagnetic source tomography (LORETA; Pascual‐Marqui & Michel, 1994; Pascual‐Marqui et al ., 1999, 2002), which belongs to a large family of tomographic procedures based on EEG linear inverse estimation (Valdes et al ., 1998; Fuchs et al ., 2001; Gross et al ., 2001; Pascual‐Marqui et al ., 2002; Sekihara et al ., 2005). In precedence, LORETA has been validated for the study of ageing in the same experimental condition and setting of the present investigation (Anderer et al ., 2003; Dierks et al ., 2000; Huang et al ., 2002; Saletu et al ., 2002; Babiloni et al ., 2004a; Goforth et al ., 2004; Babiloni et al ., 2006a, 2006b, 2006c; 2006d, 2006e).…”

Section: Introductionmentioning

confidence: 99%

Resting EEG sources correlate with attentional span in mild cognitive impairment and Alzheimer's disease

Babiloni

Cassetta²,

Binetti

et al. 2007

Eur J of Neuroscience

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Previous evidence has shown that resting delta and alpha electroencephalographic (EEG) rhythms are abnormal in patients with Alzheimer's disease (AD) and its potential preclinical stage (mild cognitive impairment, MCI). Here, we tested the hypothesis that these EEG rhythms are correlated with memory and attention in the continuum across MCI and AD. Resting eyes-closed EEG data were recorded in 34 MCI and 53 AD subjects. EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). EEG cortical sources were estimated by low-resolution brain electromagnetic tomography (LORETA). These sources were correlated with neuropsychological measures such as Rey list immediate recall (word short-term memory), Rey list delayed recall (word medium-term memory), Digit span forward (immediate memory for digits probing focused attention), and Corsi span forward (visuo-spatial immediate memory probing focused attention). A statistically significant negative correlation (Bonferroni corrected, P < 0.05) was observed between Corsi span forward score and amplitude of occipital or temporal delta sources across MCI and AD subjects. Furthermore, a positive correlation was shown between Digit span forward score and occipital alpha 1 sources (Bonferroni corrected, P < 0.05). These results suggest that cortical sources of resting delta and alpha rhythms correlate with neuropsychological measures of immediate memory based on focused attention in the continuum of MCI and AD subjects.

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Constraining EEG-MEG Source Imaging with Statistical Neuroanatomy

Cited by 35 publications

References 2 publications

Occipital sources of resting-state alpha rhythms are related to local gray matter density in subjects with amnesic mild cognitive impairment and Alzheimer's disease

Occipital sources of resting-state alpha rhythms are related to local gray matter density in subjects with amnesic mild cognitive impairment and Alzheimer's disease

Cortical responses to consciousness of schematic emotional facial expressions: A high‐resolution EEG study

Resting EEG sources correlate with attentional span in mild cognitive impairment and Alzheimer's disease

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