We study de Sitter configurations in ten-dimensional string models where supersymmetry is either absent or broken at the string scale. To this end, we derive expressions for the cosmological constant in general warped flux compactifications with localized sources, which yield no-go theorems that extend previous works on supersymmetric cases. We frame our results within a dimensional reduction and connect them to a number of Swampland conjectures, corroborating them further in the absence of supersymmetry. Furthermore, we construct a top-down string embedding of de Sitter brane-world cosmologies within unstable anti-de Sitter landscapes, providing a concrete realization of a recently revisited proposal.