Goal: To discuss the effectiveness of hormone therapy in improving female sexual function during menopause, as this phase plays an integral role in women's lives. Methodology: Bibliographic review carried out through searches in the PubMed and Scientific Electronic Library Online (SciELO) databases, with 11 articles selected to compose the collection. Results: Menopause, the female post-reproductive period, is associated with symptoms resulting from hypoestrogenism, such as mood swings, vaginal dryness, dyspareunia, among others, which significantly impact the woman's quality of life and can generate a feeling of loss of femininity. In order to minimize these impacts on sexual life, hormone replacement therapy has been widely used, due to its many benefits, including improvement in vaginal dryness, regulation of libido and female sexual arousal, increased bone mineral density and improvement in lipid profile. Final considerations: It was observed that hormone replacement therapy is currently considered the most effective and safe treatment for menopausal women, providing relief from vasomotor symptoms, reduction of hot flashes and other benefits related to female sexual health.