Constructing 4-hydroxythiazole-5-carboxamide building blocks in one pot

Abstract

4-Hydroxythiazole-5-carboxamide units have been found in many bioactive compounds. However, the yield for its overall synthetic method is as low as 10%, which limits its further broad application in novel drug discovery. Herein, we report a concise method to prepare 4-hydroxythiazole-5-carboxamides using a thioamide and monobromomalonamide (2-bromopropanediamide) in one-step with good-to-excellent yields.