Logarithm Least-Squares Support Vector Regression (LLS-SVR) has been applied in addressing forecasting problems in various fields, including bioinformatics, financial time series, electronics, plastic injection moulding, Chemistry and cost estimations. Cautious Random Particle Swarm Optimization (CRPSO) uses random values that allow pbest and gbest to be adjusted to the correct weight using a random value. CRPSO limits the random value to be conditional, to avoid premature convergence into a local optimum. If the random value is greater than 0.6, another random value is chosen. The movement of the range (cautious flow) is controlled to avoid premature convergence. This pilot study retrospectively collected data on 695 patients admitted to intensive care units and constructed a novel mortality prediction model with logarithm least-squares support vector regression (LLS-SVR) and cautious random particle swarm optimization (CRPSO). LLS-SVR-CRPSO was employed to optimally select the parameters of the hybrid system. This new mortality model can offer agile support for physicians' intensive care decision-making.