Construction and Functions of Cyclodextrin‐Based 1D Supramolecular Strands and their Secondary Assemblies

Abstract

Cyclodextrins (CDs), a class of cyclic oligosaccharides, are water-soluble, nontoxic, and commercial available with a low price, and their well-defined hydrophobic cavity can bind various organic/biological substrates. Through their molecular assembly mediated by organic, inorganic, or polymeric molecules as templates, CDs and their functional derivatives can be assembled to 1D supramolecular strands, wherein the functional groups of the CDs are closely located in a highly ordered manner. This structural feature greatly favors the cooperative effect of numerous functional groups in the supramolecular strand, as well as the interactions of the supramolecular strands with the multiple binding sites of substrates, especially biological substrates. Therefore, CD-based 1D supramolecular strands exhibit many material, biological, and catalytic functions, and these properties can be further improved through their secondary assembly. An overview of recent advances in the development of the construction and functions of CD-based 1D supramolecular strands and their secondary assemblies is given here. It is expected that the representative contributions described can inspire future investigations and lead to discoveries that promote the research of CD-based functional materials.

Photoresponsive, Water‐Soluble Supramolecular Dendronized Polymer with Specific Lysosome‐Targetable Bioimaging Application in Living Cells

“…On the other hand, cyclodextrins have been widely used as a versatile host to stabilize the supramolecular polymers . Depending on the pore size, the guest molecules could be encapsulated by cyclodextrins with high binding constants.…”

“…[16] As far as we know, there is still no report referring to the photoresponsive main chain SDP architecture by hostguest interaction.On the other hand, cyclodextrins have been widely used as a versatile host to stabilize the supramolecular polymers. [17][18][19][20] Depending on the pore size, the guest molecules could be encapsulated by cyclodextrins with high binding constants. For example, α-cyclodextrins behave as good host to capture structural units such as azobenzene, alkyl chain, polyethylene oxide.…”

Dynamic Self‐Assembly Encodes A Tri‐stable Au–TiO2 Photocatalyst

“…Stimuli‐responsive NPs, also called “smart” NPs, have emerged and attracted much attention due to their well‐developed supramolecular chemistry and tunable physical and chemical properties by reversible dynamic self‐assembly . Considering the size‐dependent properties of NPs, one of the most effective strategies for the construction of “smart” NPs involves controlling the reversible dispersion and aggregation driven by dynamic self‐assembly,[4a‐e,7,8] of which there have been some outstanding examples in successfully constructing switchable NP catalysts.…”

Self‐Assembled Peptide‐Based Nanomaterials for Biomedical Imaging and Therapy

“…Supramolecular chemistry, developed by Cram and Lehn in 1970s, provides a new perspective to “bottom‐to‐up” build up highly ordered nanostructures based on versatile molecular building blocks for sophisticated complex and biomimic function . So far, variable peptide‐based structures are designed and prepared via noncovalent interactions including ionic, hydrophobic, hydrogen bonding, and π–π stacking interactions .…”