Construction of a composite sponge containing tilapia peptides and chitosan with improved hemostatic performance

Ouyang, Qianqian; Hou, Tingting; Li, Chengpeng; Zhang, Hu; Liang, Limei; Li, Sidong; Zhong, Qingkun; Li, Puwang

doi:10.1016/j.ijbiomac.2019.07.163

Cited by 43 publications

(24 citation statements)

References 48 publications

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“…The water absorption ability of all the samples was tested. The water absorption capacity test was conducted according to the previous method [ 20 ]. AC and ACS sponges in dryness were accurately weighed and recorded as M0.…”

Section: Methodsmentioning

confidence: 99%

Bio-Multifunctional Sponges Containing Alginate/Chitosan/Sargassum Polysaccharides Promote the Healing of Full-Thickness Wounds

Quan

Wei

et al. 2022

Biomolecules

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Creation of bio-multifunctional wound dressings with potent hemostatic, antibacterial, anti-inflammatory, and angiogenesis features for bolstering the healing of full-thickness wounds is sought after for clinical applications. We created bio-multifunctional composite sponges by coupling alginate and chitosan with Sargassum pallidum polysaccharides through electrostatic interactions, calcium ion (Ca2+) crosslinking, and lyophilization. Alginate/chitosan (AC) sponges with different concentrations of Sargassum pallidum polysaccharides were obtained and termed AC, ACS—1%, ACS—2.5%, and ACS—5%. ACS—1% and ACS—2.5% sponges exhibited uniform porosity, high water vapor transmission rate, high water absorption, as well as good hemostatic and antibacterial abilities. ACS—2.5% sponges facilitated wound closure and promoted angiogenesis and re-epithelialization in the dermis. These data suggest that ACS sponges containing a certain amount of Sargassum pallidum polysaccharides could be employed for treatment of full-thickness skin wounds.

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Section: Methodsmentioning

confidence: 99%

Bio-Multifunctional Sponges Containing Alginate/Chitosan/Sargassum Polysaccharides Promote the Healing of Full-Thickness Wounds

Quan

Wei

et al. 2022

Biomolecules

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“…The water absorption capacity is a key parameter for medical hemostatic materials. A high water absorption dressing can absorb exudates to concentrate blood cells and accelerate blood coagulation [20]. Table 1 shows that the water absorption rates of CS-C/β-GP and CS-C/OP/β-GP hydrogel samples were 554.77 ± 20.43% and 584.03 ± 13.16% (n = 3), respectively, indicating an excellent water absorption capacity.…”

Section: Water Absorptionmentioning

confidence: 99%

“…Among these, marine active peptides are an essential part of investigations into aquatic active substances. Some evidence suggests that marine active peptides have antibacterial, hemostatic, and wound healing-promoting functions [18][19][20]. Oyster peptides (OP) from marine organisms are composed of active substances, such as antibacterial peptides, angiotensin I converting enzyme inhibitor peptides, and antioxidant peptides [21,22].…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Based Thermo-Sensitive Hydrogel Loading Oyster Peptides for Hemostasis Application

Zhang

et al. 2020

Materials

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Uncontrolled massive hemorrhage is one of the principal causes of death in trauma emergencies. By using catechol-modified chitosan (CS-C) as the matrix material and β glycerol phosphate (β-GP) as a thermo-sensitive agent, chitosan-based thermo-sensitive hydrogel loading oyster peptides (CS-C/OP/β-GP) were prepared at physiological temperature. The hemostatic performance of CS-C/OP/β-GP hydrogel was tested in vivo and in vitro, and its biological safety was evaluated. The results showed that the in vitro coagulation time and blood coagulation index of CS-C/OP/β-GP hydrogel were better than those of a commercial gelatin sponge. Notably, compared with the gelatin sponge, CS-C/OP/β-GP hydrogel showed that the platelet adhesion and erythrocyte adsorption rates were 38.98% and 95.87% higher, respectively. Additionally, the hemostasis time in mouse liver injury was shortened by 19.5%, and the mass of blood loss in the mouse tail amputation model was reduced by 18.9%. The safety evaluation results demonstrated that CS-C/OP/β-GP had no cytotoxicity to L929 cells, and the hemolysis rates were less than 5% within 1 mg/mL, suggesting good biocompatibility. In conclusion, our results indicate that CS-C/OP/β-GP is expected to be a promising dressing in the field of medical hemostasis.

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“…Moreover, many marine products are derived from naturally occurring active components with speci c properties, also including marine-appropriate peptides, which would be a critical feature of aquatic active ingredient analysis. According to some ndings, marine active peptides have antimicrobial, hemostatic, and wound healing functions [11][12][13]. Oyster peptides (OP) are active substances found in marine organisms that include antiseptic peptides and angiotensin I, in order to convert enzyme inhibitor peptides and antioxidant peptides [14,15].…”

Section: Introductionmentioning

confidence: 99%

Novel Platform Assays for the Diagnosis of Hemostatic Disorders: A Systematic Review

Alzahrani

2022

Preprint

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Background In hemostasis research the novel platform assays for the diagnosis of hemostatic disorders were limited. The purpose of the present review study would be to make a comparison between several assays for assessing the novel hemostatic techniques used in the diagnosis of coagulation disturbance and to point out the most advantageous and disadvantageous aspects of each method as a predictor of morbidity and mortality to determine hemostatic efficacy as well as biological safety. Methods The current systematic review follows the guidelines for observational studies in epidemiology and the PRISMA guidelines. The keywords were used to search the electronic databases (PubMed) (a novel platform to evaluate hemostasis). Searches were restricted to articles published between December 2016 and December 2021; original articles were written in English. To summarize, we collected bibliographies of abstract articles published on a novel platform to evaluate hemostasis studies, Results Following the removal of duplicates, articles were determined by examining the titles and abstracts. Disagreements were resolved through consensus and the application of novel hemostatic analysis methods. The researchers independently reviewed the relevant studies of the recognized records (n = 503), excluding duplicates (n = 9) and irrelevant studies (249). The remaining 254 studies were read in their entirety, and the data from the seven included studies had been extracted Conclusion Nanotechnology-Based Published study formulations discovered it is more optimal for some lab tests when expressed as an anticoagulant for the in vivo evaluation of nanoparticle implications on the complement system, and flow cytometer evaluation could be a promising platform approach for use in hemostasis managers.

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Construction of a composite sponge containing tilapia peptides and chitosan with improved hemostatic performance

Cited by 43 publications

References 48 publications

Bio-Multifunctional Sponges Containing Alginate/Chitosan/Sargassum Polysaccharides Promote the Healing of Full-Thickness Wounds

Bio-Multifunctional Sponges Containing Alginate/Chitosan/Sargassum Polysaccharides Promote the Healing of Full-Thickness Wounds

Chitosan-Based Thermo-Sensitive Hydrogel Loading Oyster Peptides for Hemostasis Application

Novel Platform Assays for the Diagnosis of Hemostatic Disorders: A Systematic Review

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