Construction of gender-specific regression models for aortic length estimation based on computed tomography images

Zemtsovskaja, Galina; Pilt, Kristjan; Samarin, Andrei; Abina, Jelena; Meigas, Kalju; Viigimaa, Margus

doi:10.1007/s12553-019-00391-8

Cited by 2 publications

(2 citation statements)

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“…The aortic length characterizes the natural history of the ascending thoracic aortic aneurysm, and the measure of it is used to develop the new predictive tools to improve the risk stratification [ 14 , 15 , 16 , 17 ]. It is measured as the distance from the aortic annulus to the origin of the innominate artery [ 14 ].…”

Section: Assessment Of Aortic Dimensions For Risk Stratificationmentioning

confidence: 99%

“…The patients with dilated (45–54 mm) and elongated (≥120 mm) ascending aortas represent high-risk candidates for pre-emptive surgery though this study is also retrospective, and the group of patients that was used is small [ 16 ]. Accurate aortic length measurements also allow for precise pulse wave velocity assessments, which are helpful for the risk stratification [ 17 ].…”

Section: Assessment Of Aortic Dimensions For Risk Stratificationmentioning

confidence: 99%

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Existing and Emerging Approaches to Risk Assessment in Patients with Ascending Thoracic Aortic Dilatation

et al. 2022

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Ascending thoracic aortic aneurysm is a life-threatening disease, which is difficult to detect prior to the occurrence of a catastrophe. Epidemiology patterns of ascending thoracic aortic dilations/aneurysms remain understudied, whereas the risk assessment of it may be improved. The electronic databases PubMed/Medline 1966–2022, Web of Science 1975–2022, Scopus 1975–2022, and RSCI 1994–2022 were searched. The current guidelines recommend a purely aortic diameter-based assessment of the thoracic aortic aneurysm risk, but over 80% of the ascending aorta dissections occur at a size that is lower than the recommended threshold of 55 mm. Moreover, a 55 mm diameter criterion could exclude a vast majority (up to 99%) of the patients from preventive surgery. The authors review several visualization-based and alternative approaches which are proposed to better predict the risk of dissection in patients with borderline dilated thoracic aorta. The imaging-based assessments of the biomechanical aortic properties, the Young’s elastic modulus, the Windkessel function, compliance, distensibility, wall shear stress, pulse wave velocity, and some other parameters have been proposed to improve the risk assessment in patients with ascending thoracic aortic aneurysm. While the authors do not argue for shifting the diameter threshold to the left, they emphasize the need for more personalized solutions that integrate the imaging data with the patient’s genotypes and phenotypes in this heterogeneous pathology.

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